肿瘤相关巨噬细胞在胆囊癌中作用的研究进展  

Research progress of the roles of tumor-associated macrophages in gallbladder cancer

作　　者：袁梓恒 胡莹[1] 翟秀伟[1] YUAN Ziheng;HU Ying;ZHAI Xiuwei(Department of Clinical Laboratory,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,Yunnan Province,China)

机构地区：[1]昆明医科大学第二附属医院检验科,云南昆明650101

出　　处：《肿瘤》2023年第10期821-828,共8页Tumor

基　　金：云南省高层次卫生计生技术人才培养(D-2018041);国家放射与治疗临床医学研究中心分中心(202102AA100067);云南省教育厅科学研究基金项目(2022J0218)

摘　　要：胆囊癌(gallbladder cancer,GBC)是一种常见的胆道系统恶性肿瘤,往往预后不良,晚期患者的5年生存率不到10%,手术是唯一有效的治疗方法。肿瘤微环境(tumor microenvironment,TME)在GBC的发生、发展和预后中起着重要作用。肿瘤相关巨噬细胞(tumor-associated macrophage,TAM)是TME中浸润最多的免疫细胞之一,存在于GBC进展的所有阶段。本文总结巨噬细胞在GBC发展过程中经历的动态表型转变,讨论TAM对GBC进展带来的影响及TAM作为GBC治疗靶点的潜力,指出TAM参与GBC进展的机制及其与免疫抑制性TME的构建相联系的可能方式,对TAM的生物学特性及它们在GBC中的作用进行归纳和分析,以期为GBC治疗的发展和创新提供参考。Gallbladder cancer(GBC)is a common malignancy of the.biliary system with a poor diagnosis.The 5-year survival rate for patients with advanced GBC is less than 10%.Surgery is the only effective treatment for this disease.Tumor microenvironment(TME)plays an important role in GBC tumorigenesis,progression and prognosis.Tumor-associated macrophages(TAMs)are among the most abundant immune cells infiltrating the TME and are present in all stages of GBC progression.This review has summarized the dynamic phenotypic transformation that macrophages undergo during!GBC progression,discussed the impact that TAMs bring to GBC progression and the therapeutic potential of TAM-targeted strategies,and proposed the possible ways in which.TAM are involved in the mechanism of GBC progression and are linked to the construction of the immunosuppressive TME.A generalization and analysis of the biological properties of TAM and their roles in GBC was carried out in the hope to provide reference for the development and innovation of GBC therapies.

关 键 词：胆囊癌 肿瘤相关巨噬细胞 肿瘤微环境 肿瘤治疗 

分 类 号：R735.8[医药卫生—肿瘤]