加减白虎加人参汤颗粒治疗2型糖尿病(火热炽盛型)量效关系的研究  

Dose-Effect Relationship of Modified Baihu Renshen Granules(加减白虎加人参汤颗粒)in the Treatment of Type 2 Diabetes Mellitus with Huorechisheng(火热炽盛)Syndrome

作　　者：李慧 冯皓月 岳仁宋[2] 何成诗[1] 张美林[1] 袁松柏[1] 夏晓辉 黄玲玲[1] 杨蕻[1] 张新霞[2] Li Hui;Feng Haoyue;Yue Rensong;He Chengshi;Zhang Meilin;Yuan Songbai;Xia Xiaohui;Huang Lingling;Yang Hong;Zhang Xinxia(School of Acupuncture and Moxibustion,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 611731;Hospital of Chengdu University of TCM,Chengdu 610075)

机构地区：[1]成都中医药大学附属医院针灸学校,成都611731 [2]成都中医药大学附属医院,成都610075

出　　处：《中药药理与临床》2022年第1期172-176,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：四川省科技厅重点研发项目(编号:2017SZ0072)

摘　　要：目的:观察不同剂量的加减白虎加人参汤颗粒治疗2型糖尿病(火热炽盛型)的临床疗效及安全性。方法:将99例初次诊断为2型糖尿病(火热炽盛型)的患者随机分为低剂量组(30例)、中剂量组(32例)、高剂量组(31例)。各试验组予以基础治疗联合不同剂量的加减白虎加人参汤颗粒,上述治疗持续8 w。治疗前、治疗第4 w和治疗结束时,分别抽取患者的静脉血,对空腹血糖(Fasting plasma glucose,FPG)、餐后2 h血糖(Two hour postprandial glucose,2 hPG)含量、糖化血红蛋白(Glycosylated hemoglobin,HbA1c)进行测定;对治疗前、治疗结束时的中医临床疗效进行评估。结果:治疗结束时,低剂量组总有效率为66.67%,中剂量组总有效率为84.38%,高剂量组总有效率为93.55%,总有效率随着剂量增加而增高(P<0.05);各组血清HbA1c值随着剂量增加明显降低(P<0.05)。在治疗第4 w和治疗结束时,各组的血清FPG、2 hPG值随着剂量增加而明显降低(P<0.05)。同一试验组不同治疗阶段的血清FPG、2 hPG值,随着治疗时间的延长明显降低(P<0.05)。各组治疗前后安全性指标无差异。结论:在基础治疗上使用不同剂量的加减白虎加人参汤颗粒治疗2型糖尿病(火热炽盛型)对FPG、2 hPG、HbA1c和中医疗效等指标的改善均有一定的效果,且与中药的剂量呈正相关。Objective:To observe the clinical efficacy and safety of different doses of Modified Baihu Renshen Granules(加减白虎加人参汤颗粒)in the treatment of type 2 diabetes mellitus(T2DM)of Huorechisheng(火热炽盛)syndrome.Methods:A total of 99 patients initially diagnosed with T2DM of Huorechisheng(火热炽盛)syndrome were randomized into low-dose group(30 cases),medium-dose group(32 cases),and high-dose group(31 cases).Each experimental group was given basic treatment combined with different doses of Modified Baihu Renshen Granules(加减白虎加人参汤颗粒),and the administration lasted 8 weeks.Before treatment,at the 4th week of treatment,and after treatment,venous blood of the patients was collected,respectively,and then levels of fasting plasma glucose(FPG),two-hour postprandial glucose(2 hPG),and glycosylated hemoglobin(HbA1c)were determined.The clinical efficacy of traditional Chinese medicine was evaluated before and after treatment.Results:At the end of treatment,the total effective rate was 66.67%in low-dose group,84.38%in medium-dose group,and 93.55%in high-dose group,which increased with the dose(P<0.05).The serum HbA1c value significantly decreased with the increase of dose(P<0.05).At the 4th week and the end of treatment,the FPG and 2 hPG values significantly reduced with the rise of dose(P<0.05).The values of FPG and 2 hPG in the same experimental group decreased over the treatment time(P<0.05).No significant difference was observed in clinical safety indexes in each group before and after treatment.Conclusion:On the basis of basic treatment,different doses of Modified Baihu Renshen Granules(加减白虎加人参汤颗粒)can improve FPG,2 hPG,HbA1c,and TCM efficacy in the treatment of T2DM of Huorechisheng(火热炽盛)syndrome,which is positively correlated with the dose.

关 键 词：加减白虎加人参汤颗粒 2型糖尿病 量效关系 临床研究 

分 类 号：R259[医药卫生—中西医结合]