早产儿低甲状腺素血症研究综述  

A review of studies on yypothyroidism in premature infants

作　　者：陈冰汝 郑靖阳 周丽 CHEN Bing-ru;ZHENG Jing-yang;ZHOU Li(Department of Neonatology,Wenzhou Central Hospital,Wenzhou,325000,China)

机构地区：[1]温州市中心医院新生儿科,浙江温州325000

出　　处：《中国优生与遗传杂志》2020年第4期521-526,共6页Chinese Journal of Birth Health & Heredity

摘　　要：近年来,极低胎龄早产儿(24-28w)的存活率大大提高,也由此产生了大量患有严重神经发育障碍的幸存者,他们可表现为认知和神经功能障碍(包括痉挛)[1]、感音神经性听力损失[2]及视觉空间缺陷[3-6]等。有研究表明,在先天性甲状腺功能减退的情况下,新生儿延迟2w服用甲状腺激素,智商就会下降6-8个百分点以上[7-9]。因此,低T4被发现是新生儿神经发育不良结局的一个有效危险因素,其在出生后大脑成熟度方面持续发生重大变化[10-15]。In recent years,the survival rate of very low gestational age preterm infants(24-28 weeks)has been greatly improved,resulting in a large number of survivors with severe neurodevelopmental disorders,which can be manifested as cognitive and neurologic dysfunction(including spasticity)[1],sensorineural hearing loss[2]and visual space deficiency[3-6].Some studies have shown that in the case of congenital hypothyroidism,if newborns delay taking thyroid hormone for two weeks,their IQ will drop by more than 6-8 percentage points[7-9].Therefore,low T4 was found to be an effective risk factor for the outcome of neonatal neurodysplasia,with significant changes in postnatal brain maturity[10-15].

关 键 词：极低胎龄早产儿 低甲状腺素血症 神经发育 

分 类 号：R722.6[医药卫生—儿科]