咳喘凝胶贴膏皮肤安全性考察  

Study on the Skin Safety of Kechuan Cataplasms

作　　者：王薇[1,2] 何志伟 杨柳 孙晓静[1,2] 李力 李婷[1,2] 解小霞 张义生[1,2] 范彦博 Wang Wei;He Zhiwei;Yang Liu;Sun Xiaojing;Li Li;Li Ting;Xie Xiaoxia;Zhang Yisheng;Fan Yanbo(Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430040,China;Traditional Chinese Medicine Laboratory,Wuhan Research Institute of Chinese Medicine;Xiangyang Hospital of Traditional Chinese Medicine)

机构地区：[1]武汉市中医医院,武汉430040 [2]武汉市中医药研究所国家中管局中药制剂三级试验室 [3]襄阳市中医医院

出　　处：《中国药师》2020年第3期569-572,共4页China Pharmacist

基　　金：武汉市临床医学科研项目(编号:WZ17B06);武汉市科技计划项目(编号:2017060201010219).

摘　　要：目的:制备咳喘凝胶贴膏,并进行皮肤安全性评价。方法:将处方药材经水煎煮提取、浓缩制成一定比例的药液加入凝胶贴膏基质并快速涂抹,制成凝胶贴膏;分别进行大鼠皮肤急性毒性、家兔皮肤刺激性、豚鼠皮肤过敏性试验,观察咳喘凝胶贴膏对动物经皮给药的急毒性、刺激性和过敏性。结果:皮肤急性毒性试验中,大鼠完整皮肤及破损皮肤均未出现红斑及水肿;皮肤刺激性试验中,家兔完整及破损皮肤组未出现异常情况;豚鼠皮肤过敏性试验中,咳喘凝胶贴膏低剂量及高剂量组均无过敏反应。结论:咳喘凝胶贴膏临床剂量用于大鼠、家兔及豚鼠皮肤安全、可靠。Objective:To prepare Kechuan cataplasms and evaluate the skin safety.Methods:The medicinal materials in the formula were boiled and extracted by water,and concentrated to make a certain proportion of medicinal solution.The cataplasm matrix was added and quickly applied to make the gel paste.The acute skin toxicity in rats,skin irritation in rabbits,and skin sensitization in guinea pigs were carried out to observe the acute toxicity,irritation and allergic effect of Kechuan cataplasms on transdermal administration of animals.Results:In the acute skin toxicity test,there was no erythema and edema in the intact skin and damaged skin of rats.In the skin irritation test,there was no abnormality in the intact and damaged skin group of rabbits.In the guinea pig skin allergy test,there was no allergic reaction in Kechuan cataplasms at low and high dose groups.Conclusion:The clinical dose of Kechuan cataplasms is safe and reliable for the skin of rats,rabbits and guinea pigs.

关 键 词：凝胶贴膏 皮肤安全性 急性毒性 刺激性 过敏性 

分 类 号：R285.5[医药卫生—中药学]