微生物-肠-脑轴在阿尔茨海默病中的作用及中药干预研究进展  

Research Progress on Microbiota-Gut-Brain Axis in Alzheimer’s Disease and Traditional Chinese Medicine Intervention

作　　者：厉颖 徐敏 龙宇 尹子丽 高鹏飞 LI Ying;XU Min;LONG Yu;YIN Zili;GAO Pengfei(Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali University,Dali 671000,Yunnan,China;Yunnan Provincial Academy of Science and Technology,Kunming 650031,Yunnan,China;The Second Hospital of Nanhua University,Hengyang 421001,Hunan,China;College of Chinese Ethnic Medicine,Yunnan University of Chinese medicine,Kunming 650500,Yunnan,China)

机构地区：[1]云南省昆虫生物医药研发重点实验室,云南大理671000 [2]云南省科学技术院,云南昆明650031 [3]南华大学附属第二医院,湖南衡阳421001 [4]云南中医药大学民族医药学院,云南昆明650500

出　　处：《中华中医药学刊》2022年第5期152-157,共6页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81260676,81960712);中国国家留学基金(201708535007);云南省教育厅科学研究基金重点项目(2013Z154);云南省地方本科高校(部分)基础研究联合专项(2018FH001-097);云南省2019年中药饮片产业发展专项资金(2019-YG-067)

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种机制复杂、发病原因不明的原发性中枢退行性疾病,目前尚缺乏有效防治方法。肠道微生物可通过肠道和大脑间的双向信息交流影响AD的发展。近年国内外的研究表明,微生物-肠-脑轴在AD调控方面具有重要的作用,许多物质可通过该途径影响AD的发展进程。综述微生物-肠-脑轴与AD间的关系,以及益生菌和中药通过微生物-肠-脑轴对AD的调节,以期为AD的机制研究和治疗提供参考。Alzheimer’s disease(AD)is a primary central degenerative disease with complicated mechanism and unknown etiology.At present,there is no effective prevention and treatment method for AD.Gut microbiota can influence AD development through a bidirectional information exchange between the gut and brain.Recent studies have shown that the microbial-gut-brain axis plays an important role in the regulation of AD,and many substances can influence the development of AD through this pathway.In this paper,the interaction between microbiota-gut-brain axis and AD as well as the regulation of AD by probiotics and traditional Chinese medicine through microbiota-gut-brain axis were reviewed in order to provide the reference for the study of the mechanism and treatment of AD.

关 键 词：阿尔茨海默病 肠道微生物 微生物-肠-脑轴 

分 类 号：R277.7[医药卫生—中医学]