灯盏花素防治糖尿病并发症的研究进展  

Progress in Prevention and Treatment of Diabetic Complications with Breviscapine

作　　者：徐丽娇 张旭 陈荣昌[2] 朱月 孙晓波[2] 孙桂波[2] XU Li-jiao;ZHANG Xu;CHEN Rong-chang;ZHU Yue;SUN Xiao-bo;SUN Gui-bo(School of Pharmacy,Engineering Research Center for Medicine,Harbin University of Commerce,Harbin 150076,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100094,China)

机构地区：[1]哈尔滨商业大学药学院,药物工程技术研究中心,哈尔滨150076 [2]中国医学科学院北京协和医学院药用植物研究所,北京100094

出　　处：《中国实验方剂学杂志》2020年第7期218-224,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81603334);北京协和医学院“协和青年基金”项目(3332016070);中国医学科学院医学与健康科技创新工程项目(2016-I2M-1-012).

摘　　要：短葶飞蓬Erigeron breviscapus是菊科飞蓬属的多年生草本植物,主要分布在我国西南地区,性寒、微苦、甘温辛,具有散寒解表、祛风除湿、活血化瘀、通经活络、消炎止痛等功效。灯盏花素是短葶飞蓬干燥全草的提取物,由黄酮类、木脂素类、香豆素类、萜类、植物甾醇等多种类型的化学成分组成。其中,黄酮类成分灯盏乙素(4’-羟基黄芩素-7-O-葡萄糖醛酸苷醛酸苷),灯盏甲素(芹菜素-7-O-葡萄糖醛酸苷)的含量占灯盏花素总量的90%以上。现代药理研究表明灯盏花素具有广泛的药理作用,包括抗氧化、抗纤维化、抗炎、抗衰老、抗血小板凝聚、降低血脂、增加血流量、改善微循环、防治肿瘤、抗脑损伤等。目前,灯盏花素已被广泛应用于糖尿病、脑供血不足、脑出血所致后遗症、高黏脂血症、脑血栓、肾病、肝病、阿尔兹海默等多种复杂疾病的治疗。尤其在对于糖尿病及其慢性并发症如糖尿病肾病、糖尿病心肌病、糖尿病足、糖尿病视网膜病变等疾病的治疗中,灯盏花素表现出了显著的疗效。此外,研究表明灯盏花素与甲钴胺、弥可保等药物联合应用可以提高治疗效果。该文就目前灯盏花素治疗糖尿病慢性并发症及其相关联合用药进行综述,试图为灯盏花素治疗糖尿病及其慢性并发症的临床应用提供具有参考价值的线索。Erigeron breviscapus,a species within the genus of Erigeron,is mainly distributed in Southwest China.It is cold in property,slightly bitter in taste,and has the effect of dispersing cold table,removing wind and dehumidification,promoting blood circulation and removing blood stasis,relieving pain and inflammation.Breviscapine is the extract of E.breviscapus.It is mainly consisted of flavonoids,lignans,coumarins,terpenes,phytosterols,etc.As the major components of breviscapine,the content of breviscapine b(4’-hydroxybaicalin-7-Oglucuronide)and breviscapine a(apigenin-7-O-glucuronide)is greater than 90%.Modern pharmacological studies have shown that breviscapine has a wide range of pharmacological effects,including anti-oxidation,anti-fibrosis,anti-inflammation,anti-aging,anti-platelet aggregation,lowering blood lipid,increasing blood flow,improving microcirculation,preventing and treating tumors,and resisting brain injury.In clinical,breviscapine has been widely used in the treatment of diabetes,cerebral insufficiency,sequelae caused by cerebral hemorrhage,hypermucolipemia,cerebral thrombosis,kidney disease,liver disease,Alzheimer’s disease,and some other complex diseases.Specially,in the treatment of diabetes and its chronic complications,such as diabetic nephropathy,diabetic cardiomyopathy,diabetic foot,diabetic retinopathy,breviscapine has showed significant efficacy.In addition,studies have demonstrated that the combined application of breviscapine,mecobalamine,and micopol can improve the therapeutic effect.In this work,the application of breviscapine in the treatment of chronic complications of diabetes mellitus and its related combination drugs were reviewed,by which we attempted to provide some valuable clues for the clinical application of breviscapine in the treatment of diabetes mellitus and its chronic complications.

关 键 词：灯盏花素 糖尿病 研究进展 作用机制 联合用药 

分 类 号：R285[医药卫生—中药学]