二甲双胍联合门冬胰岛素注射液治疗儿童1型糖尿病的有效性评价  

Effectiveness Evaluation of Metformin Combined With Insulin Aspart Injection in Treatment of Type 1 Diabetes Children

作　　者：刘子绢 LIU Zijuan(Endocrinology and Metabolism Department,Qujing City The First People's Hospital,Qujing Yunnan,655000)

机构地区：[1]云南省曲靖市第一人民医院内分泌代谢科,云南曲靖655000

出　　处：《智慧健康》2022年第6期85-87,共3页Smart Healthcare

摘　　要：目的探讨对儿童1型糖尿病患者采取二甲双胍+门冬胰岛素注射液进行治疗有效性以及可行性。方法将我院2017年7月-2020年4月收治的88例儿童1型糖尿病患者数字奇偶法分组;联合用药组(44例):采用二甲双胍+门冬胰岛素注射液展开糖尿病治疗;单一用药组(44例):采用门冬胰岛素注射液展开糖尿病治疗;就组间低血糖发生次数、胰岛素日用量、血糖达标时间、住院天数、不同时间段2hBG水平、FBG水平以及总不良反应率展开对比。结果联合用药组儿童1型糖尿病患者低血糖发生次数、胰岛素日用量少于单一用药组明显,血糖达标时间、住院天数短于单一用药组明显(P<0.05);治疗前,联合用药组儿童1型糖尿病患者2hBG、FBG水平同单一用药组比较差异不明显(P>0.05),治疗后,联合用药组2hBG、FBG水平低于单一用药组明显(P<0.05);两组儿童1型糖尿病患者不良反应集中于低血糖、腹泻以及恶心呕吐几方面;最终发现联合用药组总不良反应率(2.27%)低于单一用药组(15.91%)明显(P<0.05)。结论二甲双胍+门冬胰岛素注射液药物有效应用,可实现儿童1型糖尿病患者低血糖发生次数、胰岛素日用量减少,血糖达标时间、住院天数缩短,2hBG水平、FBG水平降低以及不良反应减少,最终实现儿童1型糖尿病患者有效预后。Objective To explore effectiveness and feasibility of metformin plus Insulin aspart injection in treatment of type 1 diabetes of children.Methods The paper chose 88 cases type 1 diabetes children in our hospital from July 2017 to April 2020,and divided them into groups by digital parity.Combined medication group(44 cases):diabetes mellitus was treated with metformin plus Insulin aspart injection.Single medication group(44 cases):with insulin aspart injection.Incidence of hypoglycemia,daily insulin dosage,blood glucose standard time,length of stay,2hbg level in different time periods,FBG level and total adverse reaction rate was compared.Results Incidence of hypoglycemia and insulin daily dosage of type 1 diabetes children in combination medication group was significantly lower than single medication group.Blood glucose standard-reaching time and length of stay was shorter than single medication group,(P<0.05).Before treatment,2hBG and FBG levels in combination group was not significantly different from single medication group,(P>0.05).After treatment,2hbg and FBG levels in combined drug group were significantly lower than single medication group(P<0.05).Averse reactions between two groups were concentrated on hypoglycemia,diarrhea and nausea and vomiting.Finally,it was found that total adverse reaction rate of combined drug group(2.27%)was significantly lower than single drug group(15.91%),(P<0.05).Conclusion Effective application of metformin plus insulin aspart injection can reduce incidence of hypoglycemia and insulin daily dosage of type 1 diabetes children,shorten standard-reaching time of blood sugar,shorten length of stay,reduce level of 2hBG and FBG,and adverse reactions,to achieve effective prognosis of type 1 diabetes children.

关 键 词：二甲双胍 门冬胰岛素注射液 儿童1型糖尿病 低血糖 胰岛素日用量 血糖达标时间 住院天数 2hBG水平 FBG水平 不良反应 

分 类 号：R725.8[医药卫生—儿科]