雷公藤多苷给药时间对难治性类风湿关节炎的疗效影响  

Influence of Administration Time of Tripterygium Wilfordii Polyglycoside on Curative Effect of Refractory Rheumatoid Arthritis

作　　者：赵世翔[1] 王江安 ZHAO Shixiang;WANG Jiangan(Zhenjiang City Disease Control and Prevention Center,Zhenjiang,Jiangsu,212001;Zhenjiang City Maternal and Child Health Hospital,Zhenjiang,Jiangsu,212002)

机构地区：[1]镇江市疾病预防控制中心,江苏镇江212001 [2]镇江市妇幼保健医院,江苏镇江212002

出　　处：《智慧健康》2022年第3期175-177,共3页Smart Healthcare

摘　　要：目的探究雷公藤多苷给药时间对难治性类风湿关节炎(RA)疗效影响。方法回顾性分析本中心2019年7月-2020年12月收治的78例老年难治性RA患者的病历资料。按照雷公藤多苷(TWP)给药时间将其分为甲组和乙组,2组均在甲氨蝶呤(MTX)给药的基础上联合TWP治疗,甲组(20:00给药)40例,乙组(早上8:00给药)38例。比较2组患者临床疗效及治疗后关节肿胀数、关节压痛数及晨僵时间改善情况,血清炎症因子指标[白细胞介素-6(IL-6)和IL-10]并记录不良反应情况。结果甲组治疗有效率(92.50%)高于乙组(71.05%)(P<0.05);治疗前,2组关节肿胀数、关节压痛数及晨僵时间比较无统计学差异(P>0.05);治疗后,2组上述症状均改善,且甲组改善情况均优于乙组(P<0.05);治疗后,2组患者的血清IL-6、IL-10水平较治疗前均减低,且甲组低于乙组(P<0.05)。甲组用药后不良反应发生率低于乙组(P<0.05)。结论难治性RA患者在MTX治疗的基础上,20:00 TWP给药,更有利于改善关节肿胀、关节压痛及晨僵等临床症状,提升临床治疗效果,安全性更好。Objective To explore influence of tripterygium wilfordii polyglycoside administration time on curative effect of refractory rheumatoid arthritis(RA).Methods The paper reviewed and anzlyzed medical records of 78 elderly patients with refractory RA treated in our center from July 2019 to December 2020,and divided them into group A and group B according to administration time of tripterygium wilfordii polyglycoside(TWP).Both groups were treated with methotrexate(MTX)combined with TWP,40 cases in group A(with administration time of 20:00 p.m.)and 38 cases in group B(with administration time of 8:00 a.m.).Clinical effect,improvement of joint swelling,joint tenderness and morning stiffness time after treatment,indexes of serum inflammatory factors[interleukin-6(IL-6)and IL-10]were compared between two groups,adverse reactions were recorded.Results Effective rate of group A(92.50%)was higher than group B(71.05%)(P<0.05);before treatment,there was no significant difference in number of joint swelling,joint tenderness and morning stiffness time between two groups(P>0.05);after treatment,above symptoms were improved in both groups,improvement in group A was better than group B(P<0.05);after treatment,levels of serum IL-6 and IL-10 in group A were lower than group B(P<0.05).Incidence of adverse reactions in group A was lower than group B(P<0.05).Conclusion On the basis of MTX treatment,TWP administration at 20:00 p.m.is conducive to improving clinical symptoms of refractory RA patients,including joint swelling,joint tenderness and morning stiffness,improving clinical treatment effect with better safety.

关 键 词：雷公藤多苷 给药时间 难治性类风湿关节炎 疗效 

分 类 号：R593.22[医药卫生—内科学]