含醋炔酮肟的共聚物微球的制备与体外释药初探  

PREPARATION AND DRUG RELEASE IN VITRO OF PLGA MICROSPHERES CONTAINING NORETHISTERONE OXIME ACETATE

作　　者：周芝芳[1] 韩锦文[1] 金德明 林芳[1] 沈文照 

机构地区：[1]浙江医学研究院药物研究所

出　　处：《医药工业》1988年第3期106-108,共3页

摘　　要：采用溶剂挥发法制备了含醋炔酮肟的共聚物(PLGA)微球。以体外释药试验、微球粒子大小与分布的测定,以及电镜观察等方法进行了质量考查,并选择合适的制备工艺。其中明胶的浓度、主药与PLGA的比例、溶剂挥发时的温度等因素对微球的形状、粒径大小影响较大。微球粒径小的释药较快。The PLGA microspheres containing norethisterone oxime acetatewere prepared by a solvent evaporation process.Some factors affecting shapeand diameter of microspheres,such as temperature,concentration of gelatin,and drug-PLGA ratio,were investigated.The distribution of various particle size of microspheres was examined,andthe average size was about 59μm.It was found that microspheres of the smallersize released drug more rapidly in vitro.

关 键 词：微球 醋炔酮肟 乳酸-乙醇酸共聚物 溶剂挥发法 

分 类 号：TQ3[化学工程]