光皮木瓜化学成分的分离与鉴定  

Isolation and identification of chemical constituents from Chaenomeles sinensis(Thouin) Koehne

作　　者：李孟[1,2] 张志广 石静亚[1,2] 张靖柯 吕锦锦 郑晓珂 冯卫生 LI Meng;ZHANG Zhi-guang;SHI Jing-ya;ZHANG Jing-ke;LV Jin-jin;ZHENG Xiao-ke;FENG Wei-sheng(He'nan University of Chinese Medicine,Zhengzhou 450046,China;The Engineering and Technology Center for Chinese Medicine Development of He'nan Province,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南省中药开发工程技术研究中心,河南郑州450046

出　　处：《中国药物化学杂志》2020年第8期481-486,共6页Chinese Journal of Medicinal Chemistry

基　　金：中央引导地方科技发展专项(豫财科[2016]149号);河南中医药大学2018年度博士科研基金立项(BSJJ2018-08)

摘　　要：目的研究光皮木瓜Chaenomeles sinensis(Thouin)Koehne的化学成分。方法采用Diaion HP-20、Toyopearl HW-40、MCI gel CHP-20、ODS、硅胶等柱填料并结合半制备液相等柱色谱技术对光皮木瓜提取物的化学成分进行分离,经波谱数据分析鉴定化合物的结构。结果从光皮木瓜中分离得到7个已知化合物,分别鉴定为mussaendoside X(1)、stroside A(2)、(7R,8S)-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(3)、(+)-lyoniresinol-3α-O-β-D-glucopyranoside(4)、(-)-lyoniresinol-3α-O-β-D-glucopyranoside(5)、lyonire-sinol(6)、rel-(7R,8S)-3,3′,5-trimethoxy-4′,7-epoxy-8,5′-neolignan-4,9,9′-triol-9-β-D-glucopyranoside(7),其中化合物1和2为酚苷类化合物,化合物3~7为木脂素类化合物。结论化合物1~7均为首次从该植物中分离得到。In order to study the chemical constituents of the fruits of Chaenomeles sinensis(Thouin)Koehne,two phenolic glycosides and five lignans were isolated by using chromatographic methods including Diaion HP-20,Toyopearl HW-40,MCI gel CHP-20,ODS,silica gel chromatography and semi-preparative-HPLC.These compounds were identified as mussaendoside X(1),stroside A(2),(7R,8S)-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(3),(+)-lyoniresinol-3α-O-β-D-glucopyranoside(4),(-)-lyoniresinol-3α-O-β-D-glucopyranoside(5),lyoniresinol(6),rel-(7R,8S)-3,3′,5-trimethoxy-4′,7-epoxy-8,5′-neolignan-4,9,9′-triol-9-β-D-glucopyranoside(7)on the basis of physicochemical properties and spectroscopic analysis,respectively.Compounds 1-7 were isolated from the fruits of Chaenomeles sinensis(Thouin)Koehne for the first time.

关 键 词：光皮木瓜 化学成分 酚苷 木脂素 

分 类 号：R284[医药卫生—中药学]