Insulin reverses MCP-1 suppressed cholesterol efflux to HDL3/ApoA1 through up-regulation of ABCA1,ABCG1 and SR-BI in differentiated 3T3-L1 adipocytes  

作　　者：Runlu Sun Canxia Huang Jinlan Bao Jieyu Jiang Yuling Zhang 

机构地区：[1]Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,Guangdong,China [2]The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,China

出　　处：《中国循环杂志》2018年第S01期120-121,共2页Chinese Circulation Journal

摘　　要：Objective Insulin has been reported to influence cholesterol removal from different cells,but the Results have been controversial.Based on our previous study,which we found that insulin promote cholesterol efflux from HepG2 cells and can reverse the decreased cholesterol efflux to HDL though PI3K-Akt pathway,we further investigate the effects of insulin on damaged cholesterol efflux by MCP-1 in this report.

关 键 词：MCP-1 HDL3/ApoA1 PI3K-AKT 

分 类 号：R587.1[医药卫生—内分泌]