耗竭T细胞对1型糖尿病的研究进展  

Research progress in depletion of T cells exhaustion in type 1 diabetes mellitus

作　　者：李泽颖 赵斌 李霞[1] 周智广[1] LI Zeying;ZHAO Bin;LI Xia(Department of Metabolism and Endocrinology,Second Xiangya Hospital Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院代谢内分泌科,长沙410011

出　　处：《中国糖尿病杂志》2023年第7期543-546,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(8181001262)

摘　　要：T1DM是遗传和环境因素共同作用导致的自身免疫性疾病。由于自身免疫攻击,CD8T细胞持续性破坏胰岛β细胞,胰岛β细胞血糖调节功能降低直至丧失,患者需终身依赖胰岛素治疗。免疫反应诱导免疫耐受,中断自身免疫攻击。耗竭T细胞(Tex)是外周免疫耐受的组成部分,在T细胞效应阶段发挥调节作用和胰岛β细胞功能保护相关。本文综述Tex对T1DM的研究进展。Type 1 diabetes mellitus(T1DM)is an autoimmune disease caused by genetic and environmental factors.CD8 T cells continuously destroy isletβcells due to autoimmune attack.The blood glucose regulation function of isletβcells decrease and eventually lost,and patients need to rely on Ins treatment for their whole life.Immune response induces immune tolerance and interrupts autoimmune attack.Depletion of T cells exhaustion(Tex)is a component of peripheral immune tolerance,which plays a regulatory role in the Tex effect stage and isletβcell function protection.This article reviews the research progress in Tex in T1DM.

关 键 词：糖尿病 1型 耗竭T细胞 外周免疫耐受 胰岛Β细胞 

分 类 号：R587.1[医药卫生—内分泌]