C型凝集素受体与皮肤疾病研究进展  

Recent Advances in Studies of C-type Lectin Receptors and Skin Diseases

作　　者：黄亚娇 罗晓燕[1] HUANG Yajiao;LUO Xiaoyan(Department of Dermatology,Children′s Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,National Clinical Research Center for Child Health and Disorders,China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Child Infection and Immunity,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院皮肤科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,儿童感染免疫重庆市重点实验室,重庆400014

出　　处：《中国皮肤性病学杂志》2022年第11期1334-1338,共5页The Chinese Journal of Dermatovenereology

基　　金：重庆市卫健委中青年医学高端人才项目(2019GDRC010)

摘　　要：C型凝集素受体(C-type lectin receptors, CLR)是一种髓系免疫细胞表面高表达的模式识别受体(pattern recognition receptors, PRR),通过特异性识别和摄取内外源性配体激活固有及适应性免疫应答,参与过敏、感染、自身炎症、肿瘤等多种病理过程。靶向CLR具有治疗过敏性、感染性、自身免疫性及肿瘤性皮肤病的潜力。本文将对CLR与皮肤疾病研究进展及其靶向治疗现状进行综述。C-type lectin receptors are pattern recognition receptors highly expressed on the surface of immunomyeloid cells. They can activate innate and adaptive immune response through specifically recognizing and uptaking endogenous and exogenous ligands, which involved in a variety of pathological processes such as allergy, inflammation, autoimmunity and tumor. Targeting CLR has the potential to treat allergic, infectious, autoimmune and neoplastic dermatological diseases. This review summarizes the progress of research on CLR in skin diseases and targeting therapy.

关 键 词：C型凝集素受体 靶向治疗 皮肤病 

分 类 号：R751[医药卫生—皮肤病学与性病学]