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作 者:刘慧坤[1] 李楠[1] 王蕾棽[1] 张爽[1] 李卫芹[1] 李薇[1] 胡刚 冷俊宏[1] LIU Hui Kun;LI Nan;WANG Lei Shen;ZHANG Shuang;LI Wei Qin;LI Wei;HU Gang;LENG Jun Hong(Tianjin Women and Children’s Health Center,Tianjin 300070,China;Pennington Biomedical Research Center,Baton Rouge 70808,Louisiana,USA)
机构地区:[1]天津市妇女儿童保健中心,天津300070 [2]路易斯安那州立大学彭宁顿生物研究所,美国路易斯安那州巴吞鲁日70808
出 处:《中国妇幼卫生杂志》2022年第1期62-65,共4页Chinese Journal of Women and Children Health
基 金:天津市自然科学基金(19JCYBJC28000);中国疾病预防控制中心妇幼保健中心“母婴营养与健康研究项目”(2020FYH020)
摘 要:目的探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)对学龄前子代儿童体型和血脂水平的影响。方法选取“天津市妊娠糖尿病干预随访研究”中子代儿童640例作为研究对象,按照世界卫生组织2006年儿童发育水平标准分析儿童体型,并使用《中国儿童青少年血脂防治专家共识》中推荐的血脂异常诊断标准分析儿童空腹血脂情况。结果不同年龄儿童身高体重Z评分差异无统计学意义(P>0.05)。随着年龄增加,体质指数(body mass index,BMI)Z评分增大,超重肥胖比例增加,男童的体重年龄Z评分和BMI年龄Z评分均值高于女童,差异有统计学意义(P<0.05)。所选儿童血脂异常总检出率为20.8%(133/640),未见年龄变化趋势。总胆固醇水平和异常检出率无性别差异,男童高密度脂蛋白-胆固醇水平明显高于女童,低密度脂蛋白-胆固醇、甘油三酯(total triglyceride,TG)水平明显低于女童(P<0.05),异常检出率无性别差异。不同肥胖程度儿童TG水平及异常检出率差异有统计学意义(P<0.05)。结论学龄前GDM子代儿童的生长发育、血脂异常有较明显的特点和性别差异,对于肥胖、代谢异常的个体化及群体化预防有一定指导意义。Objective To investigate the influence of gestational diabetes mellitus(GDM)on body size and blood lipid level of preschool offspring.Methods A total of 640 GDM offsprings were enrolled from“Tianjin GDM Prevention Program”.According to World Health Organization child development level standard 2006,and control of hyperlipid in children and adolescents in China was used to analyze blood lipid level.Results There was no significant difference in theZscore of height and weight among children of different ages(P>0.05).With the increasing of age,the body mass index(BMI)Zscore increased,and the proportion of overweight and obesity also increased.Boys’mean scores of weight and BMI were significantly higher than girls’(P<0.05).The total detection rate of dyslipidemia in children of GDM offspring was 20.8%(133/640).There was no significant age trend observed in the results of blood lipid test.There was no gender difference in term of level of total cholesterol and the abnormal detection rate.Density lipoprotein cholesterol among boys were higher than girls,while boys with low density lipoprotein cholesterol and total triglyceride(TG)were significantly lower than girls(P<0.05).TG level and abnormal detection rate in children of different obese degrees were significantly different(P<0.05).Conclusion Growth and development,occurrence of hyperlipid of GDM offspring at preschool age are characteristic and gender different,which is meaningful for individual and group prevention of obesity and metabolic abnormalities.
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