单硝酸异山梨醇酯联合培哚普利治疗慢性心力衰竭的疗效及对血浆N端B型钠尿肽原的影响  

Efficacy of Isosorbide Mononitrate Combined with Perindopril in the Treatment of Chronic Heart Failure and its Effects on N-Terminal B-Type Natriuretic Peptide

作　　者：刘红 刘月宾 周金锋 LIU Hong;LIU Yuebin;ZHOU Jinfeng(Dept.of Cardiology,Fuyang Hospital,Anhui Medical University,Anhui Fuyang 236000,China)

机构地区：[1]安徽医科大学附属阜阳医院心血管内科,安徽阜阳236000

出　　处：《中国医院用药评价与分析》2020年第2期211-213,217,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨单硝酸异山梨醇酯联合培哚普利治疗慢性心力衰竭的临床疗效及对血浆N末端B型钠尿肽原(NT-proBNP)的影响。方法:选取2017年12月至2018年12月安徽医科大学附属阜阳医院收治的慢性心力衰竭住院患者96例,采用随机数字表法分为观察组和对照组,每组48例。在常规治疗基础上,对照组患者采用培哚普利治疗,观察组患者采用单硝酸异山梨醇酯联合培哚普利治疗。比较两组患者的每搏输出量(SV)、每分钟心排血量(CO)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)及左心室舒张早期血流峰值速度/舒张末期血流峰值速度的比值(E/A)等指标水平,观察两组患者的治疗效果及血浆NT-proBNP水平变化情况。结果:治疗后,两组患者的SV、CO、LVEF及E/A水平均明显高于治疗前,LVEDD水平明显低于治疗前,且观察组患者上述指标水平明显优于对照组,差异均有统计学意义(P<0.05)。观察组患者的总有效率为91.67%(44/48),明显高于对照组的72.92%(35/48),差异有统计学意义(P<0.05)。治疗后,两组患者的血浆NT-proBNP水平均明显低于治疗前,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05)。结论:相较于单一使用培哚普利,单硝酸异山梨醇酯联合培哚普利治疗慢性心力衰竭,能显著改善患者心功能指标水平,降低血浆NT-proBNP水平,利于患者康复。OBJECTIVE:To probe into the efficacy of isosorbide mononitrate combined with perindopril in the treatment of chronic heart failure and its effects on N-terminal B-type natriuretic peptide(NT-proBNP).METHODS:Totally 96 patients with chronic heart failure admitted into Fuyang Hospital,Anhui Medical University from Dec.2017 to Dec.2018 were extracted to be divided into the observation group and the control group via the random number table,with 48 cases in each group.Based on conventional treatment,the control group was treated with perindopril,while the observation group received isosorbide mononitrate combined with perindopril.The stroke volume(SV),cardiac output per minute(CO),left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),and left ventricular peak diastolic blood velocity/end diastolic peak blood velocity ratio(E/A)of two groups were compared.The clinical efficacy and changes of plasma NT-proBNP levels were observed.RESULTS:After treatment,the levels of SV,CO,LVEF and E/A of two groups were significantly higher than those before treatment,and the level of LVEDD was significantly lower than that before treatment,and the levels of the above indicators in the observation group were significantly better than those in the control group,the differences were statistically significant(P<0.05).The total effective rate in the observation group was 91.67%(44/48),significantly higher than that in the control group(72.92%,35/48),with statistically significant difference(P<0.05).After treatment,the plasma NT-proBNP levels in two groups were significantly lower than those before treatment,the observation group was significantly lower than the control group,and the differences were statistically significant(P<0.05).CONCLUSIONS:Compared with perindopril alone,isosorbide mononitrate combined with perindopril in the treatment of chronic heart failure can significantly improve patient’s cardiac function,reduce the plasma NT-proBNP levels,which is conducive to rehabilitation.

关 键 词：单硝酸异山梨醇酯 培哚普利 慢性心力衰竭 血浆N末端B型钠尿肽原 

分 类 号：R541.6[医药卫生—心血管疾病]