糖尿病足溃疡患者溃疡愈合不良的影响因素  

Influencing Factors of Poor Ulcer Healing in Diabetic Foot Ulcers

作　　者：姬正丽[1] 陈增军[1] 张姗姗[1] JI Zheng-li;CHEN Zeng-jun;ZHANG Shan-shan(The First Affiliated Hospital of Henan University of Science and Technology,Henan Luoyang 471003)

机构地区：[1]河南科技大学第一附属医院,河南洛阳471003

出　　处：《深圳中西医结合杂志》2022年第19期15-18,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:分析糖尿病足溃疡(DFU)患者溃疡愈合不良的影响因素。方法:选择2019年1月至2020年11月河南科技大学第一附属医院收治的108例DFU患者为研究对象,随访6个月,根据患者溃疡愈合情况分为愈合不良组与愈合良好组,调查并记录患者基线资料及实验室指标,分析DFU患者溃疡愈合不良的影响因素。结果:随访6个月,108例患者中溃疡愈合不良31例,占28.70%;愈合不良组合并高血压、未应用封闭负压引流治疗占比高于愈合良好组,入院时血糖化血红蛋白(HbA1c)水平高于愈合良好组,入院时血清白蛋白(ALB)水平低于愈合良好组,差异具有统计学意义(P<0.05);合并高血压、未应用封闭负压引流治疗、入院时血HbA1c水平过高均为DFU患者溃疡愈合不良的危险因素(P<0.05),入院时血清ALB水平高是DFU患者溃疡愈合的保护因素(P<0.05)。结论:合并高血压、未应用封闭负压引流治疗、入院时血HbA1c水平过高及血清ALB水平过低均会增加DFU患者溃疡愈合不良风险,临床需针对上述因素制定针对性措施进行干预,促进溃疡愈合,改善患者预后。Objective To analyze the influencing factors of poor ulcer healing in patients with diabetic foot ulcer(DFU).Methods A total of 108 patients with DFU admitted to the First Affiliated Hospital of Henan University of Science and Technology from January 2019 and November 2020 were selected as the research object,the patients were followed up for 6 months and according to the patients with ulcer healing situation were divided into poor healing group and good healing group,the baseline data and laboratory indexes were investigated and recorded,the influence factors of poor ulcer healing DFU patients were analyzed.Results After 6 months of follow-up,among 108 patients,31 cases had poor ulcer healing,accounting for 28.70%;The proportion of the poor healing group with hypertension and no use of closed negative pressure drainage was higher than that of the good healing group,the level of glycated hemoglobin(HbA1c)at admission was higher than that of the good healing group,and the level of serum albumin(ALB)at admission was lower than that of the good healing group,with statistically significant differences(P<0.05).Hypertension,no vacuum sealing drainage treatment,and high blood HbA1c level at admission were the risk factors for poor ulcer healing in the DFU patients(P<0.05),and high serum ALB level at admission was a protective factor for ulcer healing in DFU patients(P<0.05).Conclusion Combined hypertension,closed negative pressure drainage treatment,high blood HbA1c level and low serum ALB level at admission can increase the risk of poor ulcer healing in DFU patients.Clinical interventions should be formulated according to the above factors to promote ulcer healing and improve the prognosis of patients.

关 键 词：糖尿病足溃疡 封闭负压引流 糖化血红蛋白 白蛋白 

分 类 号：R587.2[医药卫生—内分泌]