鼻及鼻咽部疾病与EB病毒关系的探讨  

Discussion on the Relationship Between Nasal and Nasopharyngeal Diseases and Epstein-barr Virus

作　　者：窦前 周勇 张玉振 秦双林 DOU Qian;ZHOU Yong;ZHANG Yu-zhen;QIN Shuang-lin(Guangzhou Cadre Health Management Center,The 11th People's Hospital of Guangzhou,Guangdong Guangzhou 510530)

机构地区：[1]广州市干部健康管理中心广州市第十一人民医院,广东广州510530

出　　处：《深圳中西医结合杂志》2022年第19期8-11,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广州市科技计划项目(201904010153)

摘　　要：目的:观察鼻及鼻咽部疾病与EB病毒感染之间的关系。方法:收集2019年9月至2020年12月期间广州市干部健康管理中心电子鼻咽镜检查的资料,统计所有研究对象电子鼻咽镜检查及EB病毒检测的结果,比较不同EB病毒感染的鼻咽镜检查疾病的发病率。结果:711例研究对象中,EB病毒衣壳蛋白抗原(VCA)-免疫球蛋白A(IgA)抗体阳性234例,阴性477例;EB病毒核抗原1(NA1)-IgA抗体阳性93例,阴性618例;两项均为阳性者23例,均为阴性407例。鼻咽镜检查异常的结果中,鼻咽炎的发病率最高,EB病毒NA1-IgA抗体阳性者鼻咽癌的发病率明显高于阴性者,EB病毒VCA-IgA抗体阴性者鼻息肉的发病率明显高于阳性者,两项均阳性者鼻咽癌的发病率明显高于阴性者,差异均具有统计学意义(P<0.05)。结论:EB病毒与鼻及鼻咽部相关疾病的发生具有一定相关性,EB病毒VCA-IgA抗体阳性和NA1-IgA抗体阳性患者中鼻咽炎的发病率较高,两者可能分别参与鼻息肉和鼻咽癌的发生,但仍需进一步研究。Objective To investigate the relationship between epstein-barr virus(EB)infection and nasal and nasopharyngeal diseases.Methods The data of electronic nasopharyngoscopy in Guangzhou Cadre Health Management Center from September 2019 to December 2020 were collected.The results of electronic nasopharyngoscopy EB virus detection of all the research subjects were statistically analyzed,and the incidence of different EB virus infection by nasopharyngoscopy was compared.Results Among 711 subjects,there were 234 cases of EB virus viral capsid antigen(VCA)-immunoglobulin A(IgA)antibody positive and 477 cases of EB virus VCA-IgA antibody negative.There were 93 cases positive for EB virus nuclear antigen 1(NA1)-IgA antibody and 618 cases negative.There were 23 cases with both positive and 407 cases with both negative results.Among the abnormal results of nasopharyngeal endoscopy,nasopharyngitis had the highest incidence.The incidence of nasopharyngeal carcinoma was significantly higher in patients with EB virus NA1-IgA antibody positive than that in patients with EB virus NA1-IgA antibody negative.The incidence of nasal polyps was significantly higher in patients with EB virus VCA-IgA antibody negative than that in patients with EB virus VCA-IgA antibody positive than that in patients with EB virus VCA-IgA antibody positive.The differences were all statistically significant(P<0.05).Conclusion EB virus has a certain correlation with the occurrence of nasal and nasopharyngeal related diseases.Patients with positive EB virus VCA-IgA antibody and NA1-IgA antibody have a higher incidence of nasopharyngitis,which may be involved in the occurrence of nasal polyps and nasopharyngeal carcinoma respectively,but further studies are needed.

关 键 词：鼻疾病 鼻咽部疾病 EB病毒 鼻咽镜检查 

分 类 号：R765[医药卫生—耳鼻咽喉科]