慢性阻塞性肺疾病伴认知障碍患者同型半胱氨酸、8-羟基脱氧鸟苷酸、血清淀粉样蛋白A水平变化及其与认知功能的相关性研究  

Changes of Hcy,8-OHdG and SAA Levels in COPD Patients Accompanied with Cognitive Disorder and Their Correlations with Cognitive Function

作　　者：郭陶陶 王晶晶 袁文杏 刘敏 张向民[1] GUO Taotao(Department of Respiratory Medicine,the Second Hospital of Handan,Handan 056002,China)

机构地区：[1]河北省邯郸市第二医院呼吸内科,056002

出　　处：《实用心脑肺血管病杂志》2020年第1期49-53,59,共6页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：2019年度河北省医学科学研究课题计划(20191792).

摘　　要：背景慢性阻塞性肺疾病(COPD)患者常伴有认知障碍,但其具体发生机制目前尚不明确,而积极寻找早期诊断COPD患者认知障碍的指标具有重要临床意义。目的探讨COPD伴认知障碍患者同型半胱氨酸(Hcy)、8-羟基脱氧鸟苷酸(8-OHdG)、血清淀粉样蛋白A(SAA)水平变化及其与认知功能的相关性。方法选取2017年1月—2018年3月邯郸市第二医院呼吸内科收治的COPD患者88例,根据认知功能分为认知障碍组(n=57)和非认知障碍组(n=31);另选取同期在本院门诊体检健康者42例作为对照组。比较三组受试者蒙特利尔认知评估量表(MoCA)评分,Hcy、8-OHdG、SAA水平及其mR NA相对表达量;Hcy、8-OHdG、SAA水平及其mR NA相对表达量与COPD伴认知障碍患者MoC A评分,Hcy水平及其mR NA相对表达量与COPD伴认知障碍患者8-OHdG、SAA水平及其mR NA相对表达量的相关性采用Pearson相关分析。结果 (1)认知障碍组患者视空间与执行能力、命名、注意力、语言、抽象、延迟回忆、定向力评分及MoCA总分低于非认知障碍组、对照组(P<0.05)。(2)认知障碍组患者Hcy、8-OHdG、SAA水平及其mRNA相对表达量高于非认知障碍组、对照组(P<0.05);非认知障碍组患者Hcy、SAA水平及其mRNA相对表达量高于对照组(P<0.05)。(3)Pearson相关分析结果显示,Hcy、8-OHdG、SAA水平及其m RNA相对表达量与COPD伴认知障碍患者MoCA评分呈负相关(r值分别为-0.456、-0.677、-0.413、-0.477、-0.699、-0.478,P<0.05);Hcy水平与COPD伴认知障碍患者8-OHdG、SAA水平呈正相关(r值分别为0.335、0.442,P<0.05),且Hcy mRNA相对表达量与COPD伴认知障碍患者8-OHdG、SAA mRNA相对表达量亦呈正相关(r值分别为0.365、0.441,P<0.05)。结论 COPD伴认知障碍患者Hcy、8-OHdG、SAA水平及其mRNA相对表达量明显升高,且Hcy、8-OHdG、SAA水平及其mRNA相对表达量与COPD伴认知障碍患者认知功能损伤程度呈负相关。Background COPD patients usually accompanied with cognitive disorder,but the specific mechanism is unclear so far,therefore it is of great clinical significance to actively find diagnostic indicator for early diagnosing cognitive disorder in patients with COPD. Objective To investigate the changes of Hcy,8-OHdG and SAA levels in COPD patients accompanied with cognitive disorder and their correlations with cognitive function. Methods From January 2017 to March 2018,a total of 88 patients with COPD were selected in the Department of Respiratory Medicine,the Second Hospital of Handan,and they were divided into cognitive disorder group(n=57)and non-cognitive disorder group(n=31)according to cogntive function;a total of 42 healthy people admitted to this hospital for physical examination were selected as control group in addition. MoCA score,levels of Hcy,8-OHdG,SAA and their relative mRNA expression quantity were compared in the three groups;Pearson correlation analysis was used to analyze the correlations of Hcy,8-OHdG,SAA levels and their relative mRNA expression quantity with MoCA score,as well as Hcy and its relative mRNA expression quantity with 8-OHdG,SAA levels and their relative mRNA expression quantity in COPD patients accompanied with cognitive disorder. Results (1)Visual space and executive capability score,naming score,attention score,language score,abstract score,delayed recall score,directive force score and total MoCA score in cognitive disorder group were statistically significantly lower than those in non-cognitive disorder group and control group(P<0.05).(2)Levels of Hcy,8-OHdG,SAA and their relative mRNA expression quantity in cognitive disorder group were statistically significantly higher than those in non-cognitive disorder group and control grou(pP<0.05),meanwhile levels of Hcy,SAA and their relative mRNA expression quantity in non-cognitive disorder group were statistically significantly higher than those in control group(P<0.05).(3)Pearson correlation analysis results showed that,Hcy,8-OHdG,S

关 键 词：慢性阻塞性肺疾病 认知障碍 同型半胱氨酸 8-羟基脱氧鸟苷酸 血清淀粉样蛋白A 

分 类 号：R563.9[医药卫生—呼吸系统] R749.1[医药卫生—内科学]