托法替布成功治疗连续性肢端皮炎一例  

A case of acrodermatitis continua of Hallopeau successfully treated by tofacitinib

作　　者：马艳婷 王玮[2] MA Yan-ting;WANG Wei(Jining Medical University,Jining 272000,China)

机构地区：[1]济宁医学院,济宁272000 [2]济宁市第一人民医院

出　　处：《实用皮肤病学杂志》2023年第3期186-188,共3页Journal of Practical Dermatology

摘　　要：14岁男性患者,左无名指末端红斑、脓疱伴甲板肥厚剥离4年。皮肤科查体:左无名指末端红肿,甲板明显损毁,残留部分浑浊、变形,伴甲下脓疱。甲床组织病理:上皮角化不全伴角化过度,棘层轻度增厚,角质层可见中性粒细胞聚集,真皮浅层血管扩张、充血,周围少许中性粒细胞浸润。诊断:连续性肢端皮炎。治疗:口服异维A酸胶囊、环孢素无效,予以口服托法替布、外用卡泊三醇倍他米松软膏,治疗6周后患者症状明显缓解,停托法替布,继续外用卡泊三醇倍他米松软膏维持治疗,随访3个月无复发。A 14-year-old male patient presented with repeat erythema and pustules beneath the fingernail in the fourth finger for 4 years.Physical examination revealed clustering pustules and erythema on the end of the fourth finger.Pustulation of the nail bed and the nail matrix leaded to loss of the nail plate.Histopathology showed hyperkeratosis,parakeratosis,mild acanthosis with neutrophils in the stratum corneum.Dilated vessels with few lymphocytic infiltrate were observed in the papillary dermis.The patient was diagnosed as acrodermatitis continua of Hallopeau.There was no progress with the treatment of ciclosporin and isotretinoin.Therefore,we initiated tafacitinib therapy(10mg/d)with betamethasone cream.Six weeks later,the patient’s condition was alleviated by the treatment,and the erythema and pustules regressed.No recurrence was observed during the 3 months follow-up.

关 键 词：肢端皮炎 连续性 托法替布 

分 类 号：R758.69[医药卫生—皮肤病学与性病学]