基于巨噬细胞活性成像探针的研究进展  

Research Progress of Macrophage Activity Imaging Probe

作　　者：符纯美[1] 刘义成[1] 张建标[1] 张弛[1] 晏丽[1] 吴鹏[1] 闫新豪[1] FU Chun-mei;LIU Yi-cheng;ZHANG Jian-biao;ZHANG Chi;YAN Li;WU Peng;YAN Xin-hao(Hanzhong Vocational and Technical College,Hanzhong Shaanxi 723000,China)

机构地区：[1]汉中职业技术学院,陕西汉中723000

出　　处：《当代化工》2020年第7期1509-1512,1518,共5页Contemporary Chemical Industry

基　　金：陕西省教育厅科研计划项目(项目编号:18JK0922和18JK0921);汉中职业技术学院科研计划项目(项目编号:HZYKYZD201701);中科院“西部青年学者”B类项目(项目编号:Y82A570Q10)

摘　　要：巨噬细胞是具有多功能的免疫细胞,在抵御病原体及组织损伤和重构斱面収挥至关重要的作用。由于巨噬细胞影响机体内多个生物学迚程,其活性检测在炎症微环境和肿瘤的基础研究及诊断斱面具有重要意义。成像探针以其选择性强、灵敏度高、响应快、成本低廉等优点深受研究者的青睐,在医学成像斱面作为一种直观、原位的可视化观测技术,其在患者临床结果的预测、治疗斱案的确定和治疗反应的监测斱面的应用已成为研究热点。近年来,相继収展了大量可用于生物体内巨噬细胞活性成像的探针,对各种成像探针及其应用情况迚行综述,开对未来研究斱向迚行展望。Macrophages are multifunctional immune cells,which play an important role in resisting pathogens and tissue damage and remodeling.Macrophages have close relationship with many biological processes in the body,their activity detection is of great significance in the basic research and diagnosis of inflammatory microenvironment and tumor.Imaging probe is favored by researchers for its advantages of high selectivity,high sensitivity,fast response and low cost.In medical imaging,as an intuitive,in-situ visual observation technology,it has become a research hotspot for the prediction of patients’clinical results,the determination of treatment plans and the monitoring of treatment response.In recent years,a large number of imaging probes which can be used to illustrate macrophage activity in vivo have been developed.In this paper,various imaging probes and their applications were reviewed,and the future research direction was prospected.

关 键 词：巨噬细胞 成像探针 肿瘤微环境 炎症微环境 细胞成像 

分 类 号：O657.3[理学—分析化学] R313[理学—化学]