参芪降糖颗粒联合迈之灵治疗非增殖期2型糖尿病视网膜病变气阴两虚、络脉瘀阻证疗效研究  

Effect of Shenqi Jiangtang granule combined with Maizhiling in treating non-proliferative 2 type diabetic retinopathy with syndrome of deficiency of both Qi and Yin and obstruction of collaterals

作　　者：段俞伽[1] 崔硕[1] 刘旭 DUAN Yujia;CUI Shuo;LIU Xu(The People’s Hospital of Langfang City in Hebei Province,Langfang 065000)

机构地区：[1]河北省廊坊市人民医院,廊坊065000

出　　处：《陕西中医》2020年第3期334-337,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河北省卫生和计划生育委员会科研项目(2017B00242).

摘　　要：目的:探讨参芪降糖颗粒联合迈之灵治疗非增殖期2型糖尿病视网膜病变气阴两虚、络脉瘀阻证的临床疗效。方法:选取收治的非增生期2型糖尿病视网膜病变患者86例,按随机数字表法分为观察组和对照组,每组43例。两组参照指南给予常规治疗措施;对照组给予迈之灵片;观察组在对照组治疗基础上给予参芪降糖颗粒。两组连续治疗12周。比较两组患者的视力、眼压、眼底检查、临床疗效以及气阴两虚、络脉瘀阻证症状评分。结果:治疗后,观察组(1.08±0.18)患者视力高于对照组(0.96±0.15)(P<0.01)。治疗后两组眼压[(14.19±2.57)mmHg、(13.98±2.71)mmHg]差异无统计学意义(P>0.05)。观察组患者治疗后血管渗漏面积(0.49±0.06)cm^2、微血管瘤个数(14.31±1.81)个、毛细血管无灌注区面积(0.52±0.07)cm^2明显少于对照组[(0.67±0.09)cm^2,(15.81±2.09)个,(0.67±0.09)cm^2],视网膜循环时间(14.65±1.90)s显著短于对照组(15.90±2.13)s(P<0.01)。观察组的总有效率为90.70%,高于对照组的总有效率69.77%(P<0.05)。治疗后,观察组患者的气阴两虚、络脉瘀阻证症状评分显著低于对照组(P<0.01)。结论:参芪降糖颗粒联合迈之灵治疗非增殖期2型糖尿病视网膜病变气阴两虚、络脉瘀阻证可提高患者的视力,改善眼底病变和中医证候,提高临床疗效。Objective:To investigate the efficacy of Shenqi Jiangtang granule combined with Maizhiling in treating non-proliferative 2 type diabetic retinopathy with syndrome of deficiency of both Qi and Yin and obstruction of collaterals.Methods:Eighty-six non-proliferative diabetic retinopathy patients admitted to the hospital from February of 2017 to April of 2019 were selected and divided into observation group and control group(43 patients in each group)according to the random number table.Both groups were given with conventional treatment with reference to the guidelines.The control group was given with Maizhiling tablets.On the basis of treatment in the control group,the observation group was orally given with Shenqi Jiangtang granule.Both groups were continuously treated for 12 weeks.The visual acuity,intraocular pressure,fundus examination,clinical efficacy,scores of synptoms of syndrome of deficiency of both Qi and Yin and obstruction of collaterals were compared between the two groups.Results:After treatment,the visual acuity(1.08±0.18)of the observation group was higher than that of the control group(0.96±0.15)(P<0.01).There was no significant difference in intraocular pressure between the two groups[(14.19±2.57)mmHg vs(13.98±2.71)mmHg]after treatment(P>0.05).After treatment,the area of vascular leakage(0.49±0.06)cm^2,the number of microhemangiomas(14.31±1.81)caseand the area of capillary non-perfusion zone(0.52±0.07)cm^2 in the observation group were significantly less than that in the control group[(0.67±0.09)cm^2,(15.81±2.09)case,(0.67±0.09)cm^2],and the retinal circulation time(14.65±1.90)s was significantly shorter than that in the control group(15.90±2.13)s(P<0.01).The total effective rate of the observation group was 90.70%,higher than that of the control group(69.77%)(P<0.05).After treatment,the scores of symptom of syndrome ofdeficiency of both Qi and Yin and obstruction of collaterals in the observation group were significantly lower than those in the control group(P<0.01).Conclusion:Shenqi

关 键 词：糖尿病视网膜病变 参芪降糖颗粒 迈之灵 气阴两虚 络脉瘀阻证 

分 类 号：R276.7[医药卫生—中医五官科学]