五酯软胶囊联合他克莫司治疗乙肝相关性膜性肾病临床研究  

Clinical study on the treatment of hepatitis B associated-membranous nephropathy with Wuzhi soft capsule combined with tacrolimus

作　　者：刘栋[1] 胡敏 张翠杰 李芳华 翟亚玲 LIU Dong;HU Min;ZHANG Cuijie(Department of Nephrology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450002)

机构地区：[1]郑州大学第一附属医院肾内科,郑州450002

出　　处：《陕西中医》2020年第3期331-333,363,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金资助项目(81600555).

摘　　要：目的:探讨益肾化瘀中药联合他克莫司胶囊对乙肝相关性膜性肾病的治疗效果。方法:选取HBV-MN病患者共80例,随机分为两组,对照组采用常规他克莫司胶囊,观察组给予他克莫司胶囊联合五酯软胶囊。结果:观察组与对照组治疗后,24h尿蛋白分别为(0.99±2.94)g/L和(2.94±1.57)g/L,血肌酐分别为(82.44±3.17)mmol/L和(101.33±2.47)mmol/L;白蛋白含量分别为(37.05±2.49)g/L和(31.47±5.27)g/L,五酯软胶囊加入后,降低了24 h尿蛋白、血肌酐,增加血液中白蛋白含量。降低肝病毒在体内的存活率。结论:益肾化瘀的五酯软胶囊联合他克莫司药物,对HBV-MN治疗有促进作用。Objective:To investigate the effect of Yishen Huayu prescription combined with tacrolimus on the treatment of hepatitis B associated-membranous nephropathy.Methods:80 patients with hepatitis B virus associated-membranous nephropathy were randomly divided into two groups.The control group received conventional tacrolimus capsule and the observation group received tacrolimus capsule combined with Wuzhi soft capsule to treat HBV-MN were patients.Results:After treatment,the urine protein in the observation group and the control group were(0.99±2.94)g/L and(2.94±1.57)g/L at 24 h,the blood creatinine was(82.44±3.17)mmol/L and(101.33±2.47)mmol/L,the albumin content were(37.05±2.49)g/L and(31.47±5.27)g/L,respectively.Reduces the survival rate of liver viruses in the body.Conclusion:Wuzhi soft capsule can significantly increase the effect of tacrolimus and promote the treatment of hepatitis B virus associated-membranous nephropathy.

关 键 词：乙肝相关性膜性肾病 他克莫司 五酯软胶囊 益肾化瘀 益气补血 

分 类 号：R512.62[医药卫生—内科学] R692.3[医药卫生—临床医学]