异丙托溴胺联合布地奈德福莫特罗粉治疗中度慢性阻塞性肺病疗效及对患者肺功能的影响研究  

Effect of ipratropium bromide combined with budesonide formoterol powder on patients with moderate chronic obstructive pulmonary disease and its effect on pulmonary function

作　　者：雍文穆[1] 邓淑娇[1] 李森[1] YONG Wenmu;DENG Shujiao;LI Sen(Department of Respiratory and Critical Care Medicine,Hanzhong Central Hospital,Hanzhong 723000)

机构地区：[1]陕西省汉中市中心医院呼吸与危重症医学科,汉中723000

出　　处：《陕西医学杂志》2020年第3期349-352,356,共5页Shaanxi Medical Journal

基　　金：四川省卫生和计划生育委员会科研课题(115784152).

摘　　要：目的:探究异丙托溴胺联合布地奈德福莫特罗粉治疗中度慢性阻塞性肺病的效果及对患者肺功能的影响。方法:选取中度慢性阻塞性肺病患者100例,按照完全随机法将所有患者分为对照组和联合用药组各50例。对照组使用布地奈德福莫特罗粉吸入剂,联合用药组使用复方异丙托溴铵溶液联合布地奈德福莫特罗粉吸入剂进行治疗。使用肺功能检测仪检测FEV1、FVC,使用酶联免疫吸附试验法检测血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6),使用全自动生化分析仪来检测血胆固醇、低密度蛋白。使用ABL90FLEX血气分析仪检测血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2),观察两组各实验室指标并对比治疗效果及不良反应。结果:治疗后联合用药组对CRP、TNF-α、IL-6、血胆固醇、低密度蛋白、PaCO2因子的降低作用显著高于对照组,PaO2表达水平高于对照组(P <0.05)。联合用药组的总有效率高于对照组(P <0.05)。联合用药组的不良反应高于对照组(P<0.05)。结论:复方异丙托溴铵溶液联合布地奈德福莫特罗粉吸入剂可有效的抑制慢性阻塞性肺病患者肺部炎症,改善患者临床症状,促进患者恢复,效果较好。Objective:To explore the effect of ipratropium bromide combined with budesonide formoterol powder in the treatment of moderate chronic obstructive pulmonary disease(COPD)and its effect on pulmonary function.Methods:100 patients with moderate COPD were randomly divided into control group and combined group,with 50 cases in each group.The control group was treated with budesonide formoterol powder inhalation,and the combined group was treated with compound ipratropium bromide solution and budesonide formoterol powder inhalation.FEV1 and FVC were detected by lung function detector.Serum C reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were detected by enzyme linked immunosorbent assay.Serum cholesterol and lowdensity protein were detected by automatic biochemical analyzer.The blood oxygen partial pressure(PaO2)and arterial carbon dioxide partial pressure(PaCO2)were measured by ABL90 FLEX blood gas analyzer.The laboratory indexes of the two groups were observed.The therapeutic effect and adverse reactions were compared between the two groups.Results:After treatment,the decrease of CRP,TNF-α,IL-6,blood cholesterol,low-density protein and PaCO2 in the combined group was significantly higher than that in the control group,and the level of PaO2 was higher than that in the control group(P<0.05).The total effective rate of the combined group was higher than that of the control group(P<0.05).The adverse reactions in the combined group were higher than those in the control group(P<0.05).Conclusion:The combination of compound ipratropium bromide solution and budesonide formoterol powder inhalation can effectively inhibit the pulmonary inflammation,improve the clinical symptoms and promote the recovery of patients with COPD.

关 键 词：复方异丙托溴胺 慢性阻塞性肺病 布地奈德福莫特罗 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]