Comparison of Thyroglobulin and Thyroid Function in Pregnant Women between Counties with a Median Urinary Iodine Concentration of 100-149 μg/L and 150-249 μg/L  

作　　者：CHEN Di Qun YE Ying WU Jia Ni LAN Ying WANG Mu Hua WU Xiao Yan HE Meng WANG Li Jin ZHENG Xin Yi CHEN Zhi Hui 

机构地区：[1]Department of Endemic Diseases,Fujian Center for Disease Control and Prevention,Fuzhou 350012,Fujian,China [2]School of Public Health,Fujian Medical University,Fuzhou 350122,Fujian,China

出　　处：《Biomedical and Environmental Sciences》2023年第10期917-929,共13页生物医学与环境科学（英文版）

基　　金：sponsored by the Fujian Provincial Health Technology Project[2020CXA020];Fujian Provincial Natural Science Funding[2020J01093];Construction of Fujian Provincial Scientific and Technological Innovation Platform[2019Y2001]

摘　　要：Objective This study explored whether thyroglobulin and thyroid disease prevalence rates were higher in pregnant Chinese women with a median urinary iodine concentration of 100-149μg/L,compared with those with a median urinary iodine concentration of 150-249μg/L maintained through sustainable universal salt iodization.Methods This was a cross-sectional study in which 812 healthy pregnant women were enrolled to collect samples of their household edible salt,urine,and blood during their routine antenatal care in the18 counties in Fujian Province,China.The levels of salt iodine concentration,urinary iodine concentration(UIC),free triiodothyronine(FT3),free thyroid hormone(FT4),thyroid-stimulating hormone(TSH),thyroglobulin(Tg),thyroid peroxidase antibody and thyroglobulin antibody were assessed during the routine antenatal care visits.Results The median UIC(m UIC)in pregnant women was 130.8μg/L(interquartile range=91.5-198.1μg/L)in the counties with an m UIC of 100-149μg/L(Group I),and 172.0μg/L(interquartile range=123.5-244.4μg/L)in the counties with an m UIC of 150-249μg/L(Group II).Goiter prevalence and thyroid nodule detection rates showed no difference between Group I and Group II(P>0.05).Except for FT4 values,the TSH,FT4,FT3,Tg and Tg values>40(μg/L)and the thyroid diseases prevalence rate(TDR)showed no significant differences between Group I and Group II(P>0.05),whether or not iodine supplementation measures were taken.Conclusion Compared with an m UIC of 150-249μg/L,not only there was no difference in thyroid morphology,but also the Tg value,rate of Tg values>40μg/L,and TDR were not higher in pregnant women in the counties with an m UIC of 100-149μg/L achieved through sustainable universal salt iodization in Fujian Province,China.

关 键 词：Pregnant women Urinary iodine concentration THYROGLOBULIN Thyroid dysfunction 

分 类 号：R714[医药卫生—妇产科学] R446.1[医药卫生—临床医学]