24-Hour Urinary Sodium Excretion Association with Cardiovascular Events:A Systematic Review and Dose-Response Meta-Analysis  

作　　者：ZHAO Dan LI Hua Min LI Chao Xiu ZHOU Bo 

机构地区：[1]Department of Clinical Epidemiology and Evidence-Based Medicine,The First Hospital of China Medical University,Shenyang 110000,Liaoning,China [2]School of Public Health,China Medical University,Shenyang 110000,Liaoning,China

出　　处：《Biomedical and Environmental Sciences》2022年第10期921-930,共10页生物医学与环境科学（英文版）

摘　　要：Objective The relationship between sodium intake and cardiovascular(CV)events remains unconfirmed.Therefore,we carried out a systematic review and dose-response meta-analysis for evaluating the potential impact of 24-hour sodium excretion on CV risk.Besides,24-hour sodium excretion was used to replace daily sodium diet intake.Methods We searched ISI Web of Science,Embase,Pub Med,and the Cochrane Library.Our study included cohort studies reporting hazard ratio(HR).The random-effects model was used for summarizing the total relative risks(RRs)between the included studies.In addition,the generalized least-squares regression was employed to fit the study model.Results A total of 9 studies involving 645,006 participants were included in this study.A significant non-linear relationship was observed between sodium excretion and CV events(P^(non-linearity)<0.001).In studies collecting 24-h urine samples,the sodium excretion and CV events risk were associated linearly(RR:1.04;95%CI:1.01,1.07).Conclusion In a linear dose-response manner,every 1 g increase in sodium intake was associated with an increased risk of CV events up to 4%.Further studies are required to validate our conclusions further.

关 键 词：Cardiovascular events META-ANALYSIS 24-h urinary sodium excretion DOSE-RESPONSE Sodium intake 

分 类 号：R54[医药卫生—心血管疾病]