Triclosan-induced Oxidative Stress Injury and Apoptosis by Regulating the PI3K/Akt/Caspase-3 Signaling Pathway in Human Renal Glomerular Endothelial Cells  

作　　者：MA Yan CHEN Chen WANG Jing Bo CHENG Jia Li SHEN Shi CHEN Xi HUO Jun Sheng 

机构地区：[1]Key Laboratory of Trace Element Nutrition,National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100050,China

出　　处：《Biomedical and Environmental Sciences》2022年第6期547-551,共5页生物医学与环境科学（英文版）

基　　金：supported by the National 13th 5-Year Key Research grant from the Ministry of Science and Technology of the People’s Republic of China[2018YFC1602104];performed under the project"Toxicity Evaluation of Key Contaminants in Health Food by Cell-based Test Models and the Mechanism Analysis"

摘　　要：Triclosan(TCS)is widely used in personal-care products because of its bactericidal and antibacterial properties.However,TCS and its toxic byproducts have been detected in aquatic environments,animals,and plants worldwide.TCS is a common phenolic environmental endocrine disruptor,and TCS in the environment enters the body mainly through diet and water.Most of the absorbed TCS is metabolized by the human kidneys and is eliminated in the urine[1].Some epidemiological studies have suggested a positive correlation between the TCS exposure level in urine and albumin(a biomarker of renal function),which could cause renal dysfunction[2].However,the potential effects of TCS on the mammalian kidney and its mechanisms are currently unknown.Consequently,we initiated an in vitro trial to study the molecular mechanism of cytotoxicity of TCS to glomeruli.

关 键 词：PI3K/AKT URINE APOPTOSIS 

分 类 号：R114[医药卫生—卫生毒理学]