Ⅰ型干扰素在犬类疾病病原学及治疗方面的研究进展  

Research Advances on Type Ⅰ Interferons Used for Understanding Etiology of Canine Diseases and Treatment of Them

作　　者：胡文 冯珣[1] 张宝宝[1] 闫志伟 徐玉生[2] 刘永生 HU Wen;FENG Xun;ZHANG Bao-bao;YAN Zhi-wei;XU Yu-sheng;LIU Yong-sheng(Gansu Police Vocational College,Lanzhou 730046;Nanchang Police Dog Base of Ministry of Public Security of the People’s Republic of China,Nanchang 330100;Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046)

机构地区：[1]甘肃警察职业学院,兰州730046 [2]公安部南昌警犬基地,南昌330100 [3]中国农业科学院兰州兽医研究所,兰州730046

出　　处：《生物技术通报》2019年第11期195-200,共6页Biotechnology Bulletin

基　　金：甘肃警察职业学院科研项目(2018GJYXM02).

摘　　要：I型干扰素(Interferons,IFNs)是一类具有免疫学活性的细胞因子。这类细胞因子广泛参与到固有免疫和适应性免疫的激活和调节过程中,从而发挥抗病毒、抑制细胞增殖、调节免疫及抗肿瘤作用。目前I型IFNs主要用于临床治疗肾癌、黑色素瘤及慢性乙肝等疾病。一些I型IFN家族成员也已用于临床治疗犬细小病毒性肠炎、猫白血病病毒及猫免疫缺陷病病毒感染,但I型IFN的临床治疗还没有广泛用于各种犬类疾病的治疗当中。主要综述了犬类动物机体中I型IFN的免疫学活性以及其激活的下游免疫信号通路的最新研究进展,旨为犬类疾病研究人员提供一些有价值的参考信息。Type I interferons(IFNs)are a group of cytokines with immunological activity.Type I IFNs can function as antiviral role,inhibit cell proliferation,and regulate immunity and anti-tumor effect by the activation and regulation of adaptive and innate immune responses.To date,type I IFNs are mainly used for the therapy of human renal cancer,melanoma and chronic hepatitis B and so on.Some members of type I IFNs have been approved for the treatment of canine parvovirus,feline leukemia virus and feline immunodeficiency virus infections.However,type I IFNs have still not been used for the treatment of canine diseases.This paper reviews the latest advances on the immunologic competence of type I IFNs and IFNs-activated down-stream immune signal pathways,aiming to offer valuable references for researchers in canine diseases.

关 键 词：干扰素 细胞因子 犬类疾病 临床治疗 

分 类 号：S858.292[农业科学—临床兽医学]