幽门螺旋杆菌感染与胃癌患者血清IL-32、IL-1β、TNF-α的关系研究  

Study on the Relationship between Helicobacter Pylori Infection and Serum IL-32, IL-1β and TNF-α in Patients with Gastric Cancer

作　　者：杜三军[1] 张娅娟[1] 孙晓冉 高会斌[1] 于永强[1] DU San-jun;ZHANG Ya-juan;SUN Xiao-ran;GAO Hui-bin;YU Yong-qiang(Department of Gastroenterology,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,075000,China)

机构地区：[1]河北北方学院附属第一医院消化内科,河北张家口075000

出　　处：《现代生物医学进展》2019年第24期4740-4743,共4页Progress in Modern Biomedicine

基　　金：河北省卫生厅科研基金项目(20180831);张家口市科技计划项目(1821049D).

摘　　要：目的:探讨幽门螺旋杆菌(Hp)感染与胃癌患者血清白介素-32(IL-32)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平的相关性。方法:分别选择151例胃癌患者(胃癌组)和100例健康者(对照组)作为研究对象,均采用14C尿素呼气试验检测Hp感染情况,记录Hp感染U值,根据检测结果将胃癌组分为Hp阳性组119例,Hp阴性组32例。采集所有研究对象空腹静脉血,采用酶联免疫吸附试验测定血清IL-32、IL-1β、TNF-α水平。比较胃癌组和对照组,Hp阴性组和阳性组之间血清IL-32、IL-1β、TNF-α水平、Hp感染U值的差异,Pearson相关性分析胃癌患者血清IL-32、IL-1β、TNF-α水平与Hp感染U值的相关性。结果:胃癌组患者血清IL-32、IL-1β、TNF-α水平以及Hp感染U值均高于对照组(P<0.05),Hp阳性组血清IL-32、IL-1β、TNF-α水平以及Hp感染U值均高于Hp阴性组(P<0.05)。胃癌患者血清IL-32、IL-1β、TNF-α水平均与Hp感染U值呈正相关(r=0.585、0.428、0.406,P<0.05)。结论:胃癌患者Hp感染可引起血清IL-32、IL-1β、TNF-α水平升高,Hp感染、IL-32、IL-1β、TNF-α可能通过联合作用促进胃癌发生和进展。Objective:To investigate the correlation between Helicobacter pylori(Hp)infection and serum levels of interleukin-32(IL-32),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)in patients with gastric cancer.Methods:151 patients with gastric cancer(gastric cancer group)and 100 healthy people(control group)were selected as the subjects of study.Hp infection was detected by14 C urea breath test,and Hp-infected U value was recorded.According to the results of detection,gastric cancer was divided into Hp positive group(119 cases)and Hp negative group(32 cases).Fasting venous blood was collected and serum levels of IL-32,IL-1βand TNF-αwere measured by enzyme-linked immunosorbent assay.The differences of serum IL-32,IL-1βTNF-αlevels and Hp-infected U value between gastric cancer group and control group,and Hp negative group and Hp positive group were compared.Pearson correlation analysis was used to analyze the correlation between serum levels of IL-32,IL-1β,TNF-αand Hp-infected U value in patients with gastric cancer.Results:The levels of serum IL-32,IL-1β,TNF-αand Hp-infected U value in gastric cancer group were higher than those in control group(P<0.05).The levels of serum IL-32,IL-1β,TNF-αand Hp-infected U value in Hp positive group were higher than those in Hp negative group(P<0.05).The levels of serum IL-32,IL-1βand TNF-αwere positively correlated with the Hp-infected U value(r=0.585,0.428,0.406,P<0.05).Conclusion:Hp infection in patients with gastric cancer can increase the levels of serum IL-32,IL-1βand TNF-α.Hp infection,IL-32,IL-1 beta and TNF-alpha may promote the occurrence and progression of gastric cancer through combined action.

关 键 词：幽门螺旋杆菌 胃癌 白介素-32 白介素-1Β 肿瘤坏死因子-Α 

分 类 号：R735.2[医药卫生—肿瘤]