灵龟八法结合火针对失眠患者睡眠质量及炎性因子水平的影响  

Effect of Linggui Bafa Combined with Fire Needling on Sleep Quality and Inflammatory Factor Levels in Insomnia Patients

作　　者：王薪景 郁小红 张舜 罗仙忠 龚燕[3] WANG Xin-jing;YU Xiao-hong;ZHANG Shun;LUO Xian-zhong;GONG Yan(Three District of Recuperation,Air Force Hangzhou Special Service Recuperation Center,Hangzhou,Zhejiang,310002,China;Department of Laboratory,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou,Zhejiang,310006,China;Department of Acupuncture,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou,Zhejiang,310006,China)

机构地区：[1]空军杭州特勤疗养中心疗养三区,浙江杭州310002 [2]杭州市中医院检验科,浙江杭州310006 [3]杭州市中医院针灸科,浙江杭州310006

出　　处：《现代生物医学进展》2019年第23期4541-4544,4573,共5页Progress in Modern Biomedicine

基　　金：浙江省中医药科技计划基金资助项目(2016ZB1179).

摘　　要：目的:探讨灵龟八法结合火针对失眠患者睡眠质量及炎性因子水平的影响。方法:选取2017年5月~2019年3月期间空军杭州特勤疗养中心收治的失眠患者97例,根据数字表法将患者分为对照组(n=48,常规针刺治疗)和研究组(n=49,灵龟八法结合火针治疗),比较两组患者治疗4周后的临床疗效,比较两组治疗前、治疗4周后的中医症状积分、炎性因子水平,比较两组治疗前、治疗2周后、4周后的睡眠质量,记录两组治疗期间不良反应情况。结果:研究组治疗4周后的临床总有效率为93.88%(46/49),高于对照组的72.92%(35/48)(P<0.05)。两组治疗4周后难以入寐、多梦易醒、头晕、心悸的症状积分均下降,且研究组低于对照组(P<0.05)。两组治疗2周后、4周后匹兹堡睡眠质量指数(PSQI)评分均较治疗前降低(P<0.05),研究组治疗4周后PSQI评分较治疗2周后降低(P<0.05),研究组治疗4周后PSQI评分低于对照组(P<0.05)。两组治疗4周后血清白介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均下降,且研究组低于对照组(P<0.05)。治疗期间对照组不良反应发生率为12.50%(6/48),研究组不良反应发生率为16.33%(8/49),两组不良反应发生率对比无统计学差异(P>0.05)。结论:灵龟八法结合火针治疗失眠患者,疗效显著,可改善患者临床症状,提高睡眠质量,并降低机体炎性因子水平,且安全性较好,具有一定的临床应用价值。Objective:To explore the effect of Linggui Bafa combined with Fire Needling on sleep quality and inflammatory factor levels in insomnia patients.Methods:97 insomnia patients who were admitted to Air Force Hangzhou Special Service Recuperation Center from May 2017 to March 2019 were selected,and they were divided into control group(n=48,routine acupuncture treatment)and study group(n=49,Linggui Bafa combined with fire needle treatment)according to the digital table method.The clinical effects of the two groups at 4 weeks after treatment were compared.The scores of TCM symptoms and levels of inflammatory factors before and 4 weeks after treatment were compared.The sleep quality of the two groups before treatment,2 weeks after treatment and 4 weeks after treatment were compared,and adverse reactions during treatment were recorded in both groups.Results:After 4 weeks of treatment,the total clinical effective rate of the study group was 93.88%(46/49),which was higher than 72.92%(35/48)of the control group(P<0.05).The symptom scores of insomnia,wakefulness,dizziness and palpitation decreased in both groups,and those in the study group were lower than those in the control group after 4 weeks of treatment(P<0.05).After 2 weeks and 4 weeks of treatment,Pittsburgh Sleep Quality Index(PSQI)scores in both groups were lower than those before treatment(P<0.05),PSQI scores after 4 weeks of treatment in the study group were lower than after 2 weeks of treatment(P<0.05),after 4 weeks of treatment,PSQI scores in the study group were lower than those in the control group(P<0.05).The levels of serum interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups decreased after 4 weeks of treatment,and the levels in the study group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 12.50%(6/48)in the control group and 16.33%(8/49)in the study group.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion

关 键 词：灵龟八法 火针 失眠 睡眠质量 炎性因子 疗效 

分 类 号：R246.6[医药卫生—针灸推拿学]