降气止血汤辅助法莫替丁对消化性溃疡急性出血患儿TXB2、6-Keto-PGF1α水平的影响  

Effect of Jiangqi Zhixue Decoction and Famotidine on the TXB2 and 6-Keto-PGF1α Levels in Children with Peptic Ulcer Acute Bleeding

作　　者：闫黎娜[1] 李彩虹[2] 周晓燕 郭彦孜[1] 何平[1] YAN Li-na;LI Cai-hong;ZHOU Xiao-yan;GUO Yan-zi;HE Ping(Department of Neonatology,the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi,712000,China;Department of Pediatrics,Luochuan Branch,Affiliated Hospital of Yan'an University,Yan'an,Shaanxi,727400,China;Department of Oncology,Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi,712000,China)

机构地区：[1]陕西中医药大学第二附属医院新生儿科,陕西咸阳712000 [2]延安大学附属医院洛川分院儿科,陕西延安727400 [3]陕西中医药大学附属医院肿瘤二科,陕西咸阳712000

出　　处：《现代生物医学进展》2019年第23期4487-4490,共4页Progress in Modern Biomedicine

基　　金：陕西省中医管理局中医药科研项目(JCPT004).

摘　　要：目的:探究降气止血汤辅助法莫替丁对消化性溃疡急性出血患儿血浆血栓烷B2(Thromboxane B2,TXB2)、6-酮前列腺素(6-keto-prostaglandin,6-Keto-PGF1α)水平的影响。方法:选择我院2015年10月-2018年10月收治的60例消化性溃疡急性出血患儿,经随机数字表法分为两组,每组30例。对照组采用法莫替丁进行治疗,研究组在对照组基础上联合降气止血汤进行治疗。对比两组的治疗总有效率、治疗前后凝血功能指标和TXB2、6-Keto-PGF1α水平的变化。结果:治疗后,研究组的治疗总有效率显著高于对照组(P<0.05);两组的凝血酶时间(Thrombin time,TT)、凝血酶原时间(Prothrombin time,PT)、凝血活酶时间(activated partial thromboplastin time,aPTT)及6-Keto-PGF1α水平均显著低于治疗前,血小板计数(Platelet count,PLT)、纤维蛋白原(Fibrinogen,Fbg)及TXB2水平均明显高于治疗前,且研究组以上指标改善更明显(P<0.05)。结论:降气止血汤辅助法莫替丁治疗消化性溃疡急性出血患儿的效果显著优于单用法莫替丁治疗,可能与其有效改善患儿的凝血功能及TXB2和6-Keto-PGF1α水平有关。Objective:To investigate the effect of Jiangqi Zhixue Decoction on the TXB2 and 6-Keto-PGF1αlevels in children with peptic ulcer acute bleeding.Methods:Sixty children with peptic ulcer acute bleeding who were admitted to our hospital from October 2015 to October 2018 were randomly divided into two groups,with 30 cases in each group.The control group was treated with famotidine,and the study group was treated with Jiangqi Zhixue Decoction on the basis of control group.The total effective rate,changes of TXB2,6-Keto-PGF1αlevels and coagulation function indicators before and after treatment were compared between two groups.Results:After treatment,the total effective rate of study group was significantly higher than that in the control group(P<0.05).The levels of TT,PT,aPTT and 6-Keto-PGF1αin the two groups were significantly lower than those before treatment,and the PLT,Fbg and TXB2 levels were significantly higher than before treatment,and the improvement of the above indicators in the study group were superior to those of the control group(P<0.05).Conclusion:Jiangqi Zhixue Decoction combined with famotidine was significantly better than motidine alone in the treatment of children with peptic ulcer acute bleeding,which may be related to the improvement of TXB2 and 6-Keto-PGF1αlevels.

关 键 词：降气止血汤 法莫替丁 消化性溃疡急性出血 血栓烷B2 6-酮前列腺素 

分 类 号：R725.7[医药卫生—儿科]