粪菌移植治疗儿童肠道外疾病的研究进展和临床应用前景  

Research progress and clinical application prospect of fecal microbiota transplantation in the treatment of children with extraintestinal diseases

作　　者：林婉婷 刘坚 LIN Wanting;LIU Jian(the Second School of Clinical Medicine,Southern Medical University,Guangzhou 510515,China;Department of Pediatrics,the People’s Hospital of Baoan Shenzhen,Shenzhen 518101,China)

机构地区：[1]南方医科大学第二临床医学院,广州510515 [2]深圳市宝安区人民医院儿科,深圳518101

出　　处：《生命的化学》2023年第2期221-226,共6页Chemistry of Life

摘　　要：肠道微生物群影响着人体的生理状况和营养吸收代谢。粪菌移植(fecal microbiota transplantation,FMT)是将健康人粪便中的功能菌群移植到患者体内,重塑肠内菌群结构进而调节人类肠道微生物群,成为新兴的治疗手段。本文回顾了近年来粪菌移植对儿童代谢性疾病、过敏性疾病与孤独症谱系障碍等肠道外疾病的运用与进展,表明粪菌移植治疗安全有效改变了肠道病理生理,有望成为治疗多种儿科疾病的技术。现就FMT在儿童肠道外疾病的应用现状及前景进行探讨。The gut microbiota influences human physiological status and nutritional absorption and metabolism.Fecal microbiota transplantation(FMT)is an emerging therapeutic tool to reshape the structure of the intestinal flora and thereby regulate the human intestinal microbiota by transplanting functional flora from healthy human faeces into patients.This paper reviewed the recent application and progress of fecal transplantation for extraintestinal diseases such as metabolic diseases,allergic diseases and autism spectrum disorders in children,showing that FMT is safe and effective in modifying intestinal pathophysiology and has the potential to be a promising technique for the treatment of many paediatric diseases.We reviewed the application status and prospect of FMT in children and adolescents with extraintestinal diseases.

关 键 词：粪菌移植 儿童青少年 临床应用 

分 类 号：R725.7[医药卫生—儿科]