中药制剂治疗新冠肺炎的机制  

The mechanism of traditional Chinese medicine preparations in the treatment of COVID-19

作　　者：刘莉 王娜 许迪魁 刘春燕 LIU Li;WANG Na;XU Dikui;LIU Chunyan(Yantai Penglai Psychological Rehabilitation Hospital,Yantai 265699,China;Yantai Penglai Traditional Chinese Medicine Hospital,Yantai 265699,China)

机构地区：[1]烟台市蓬莱区心理康复医院,烟台265699 [2]烟台市蓬莱中医医院,烟台265699

出　　处：《生命的化学》2022年第12期2222-2230,共9页Chemistry of Life

摘　　要：中医药是我国瑰宝,有着先辈们数千年的经验总结和积累。在我国抗击新冠肺炎过程中,大量临床数据表明,中医药参与度高的地区,新冠肺炎的治愈率高,转阴时间明显缩短,而且经中医药治疗后的患者几乎没有后遗症。近两年,由于中医理论的药理学分析和生物信息学分析的发展,中药治疗新冠肺炎的机制逐渐被阐明。本文重点阐述了我国在治疗新冠肺炎时几种常用中药和药方的主要活性成分和作用机制,这些活性成分可以作用于关键靶点来抑制病毒的复制与转录等。同时,中药制剂还可以调节能量代谢、免疫与炎症反应,改善临床上发热、咳嗽,甚至是严重并发症,如肺纤维化等症状。因此,在治疗新冠肺炎的过程中,选择适当的中药制剂,能够提高新冠肺炎的治愈率,缩短治疗周期。Traditional Chinese medicine(TCM)is a treasure of our country,with thousands of years of experience and accumulation of knowledge from our ancestors.A large amount of clinical data obtained during the fight against COVID-19 in China show that regions with a high participation in TCM have a high cure rate of COVID-19,a significantly shortened time to produce a negative test,and almost no sequelae.Over the past two years,based on the development of pharmacological and bioinformatics analysis of TCM theory,the mechanisms of TCM in the treatment of COVID-19 have gradually been elucidated.This paper focuses on the main active ingredients and mechanisms of TCM and prescription medication commonly used in the treatment of COVID-19 in China.These components act on key targets to interfere with the normal physiological function of the new Coronavirus,such as inhibiting its replication and transcription.At the same time,TCM preparations also regulate energy metabolism and immune and inflammatory responses,improving clinical symptoms such as fever,cough,and even severe complications including pulmonary fibrosis.Therefore,in the process of treating COVID-19,choosing appropriate TCM preparations can improve the cure rate and shorten the treatment cycle.

关 键 词：中药制剂 新冠肺炎 “三方三药” 

分 类 号：R259[医药卫生—中西医结合]