基于中西医临床病症特点的卵巢癌动物模型分析  

Analysis of Animal Models of Ovarian Cancer Based on the Clinical Characteristics of Traditional Chinese and Western Medicine

作　　者：周欣欣 刘茜茜 杜方绵 白莉[1] 苗明三[1] Zhou Xinxin;Liu Qianqian;Du Fangmian;Bai Li;Miao Mingsan(Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,郑州450046

出　　处：《世界科学技术-中医药现代化》2023年第10期3272-3278,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家中医药管理局岐黄学者(国中医药人教函2022-6),负责人:苗明三;河南省科学技术厅重大科技专项项目(201300310100):豫产道地中药材资源综合利用研究,负责人:苗明三;河南省卫生健康委员会中医药科学研究专项课题(20-21ZYZD02):中药外治机制及临床外用技术规范研究,负责人:苗明三

摘　　要：卵巢癌是一种异质性恶性肿瘤,是全球女性癌症死亡的最常见原因之一,目前没有有效的治疗方法,严重影响女性的生命健康。为深入探究卵巢癌的发病机制,研究特效药物与方法,本文对卵巢癌的中西医临床病证特点进行归纳、总结并赋值和评价,筛选出较完善的动物模型。通过中国知网、万方、Pubmed等数据库,收集并整理卵巢癌动物模型相关内容,对模型诊断指标进行赋值并进行吻合度评价。在对模型赋值中发现,自发性卵巢癌动物模型可模拟人自然卵巢癌的发病过程,此模型成模率高、相似度高,与中西医临床病证特点符合度较高。皮下瘤移植型模型和血瘀型模型与中医临床吻合度较高、相似度较高、存活时间较久。目前卵巢癌动物模型以西医模型为主,与中医证候相符合的动物模型的研究鲜见。对此提出卵巢癌动物模型的改进方向及完善评价体系的必要性,使卵巢癌动物模型更贴合临床,并为卵巢癌的中药疗效判定及探讨药理作用的探讨提供了理论基础,为后续研究卵巢癌的发病机制、治疗措施提供理论依据,以期完善符合中西医临床特点的卵巢癌病证结合的模型。Ovarian cancer is a heterogeneous malignant tumor,one of the most common causes of cancer death in women worldwide,and there is currently no effective treatment available for its treatment,which seriously affects women's life and health.In order to deeply explore the pathogenesis of ovarian cancer and study the specific therapeutic drugs and methods,this paper summarizes,summarizes,assigns and evaluates the clinical characteristics of traditional Chinese and Western medicine for ovarian cancer,and screens out a more complete animal model.Through CNKI,Wanfang,Pubmed and other databases,the relevant content of ovarian cancer animal models was collected and sorted,and the model diagnostic indicators were assigned and the consistency was evaluated.In the evaluation of the model,it is found that the animal model of spontaneous ovarian cancer can simulate the pathogenesis process of human natural ovarian cancer,and the model has high modulus rate,high similarity,and high consistency with the clinical characteristics of traditional Chinese and Western medicine.The subcutaneous tumor graft type model and the blood stasis type model were in good clinical agreement with traditional Chinese medicine,a high degree of similarity,and a longer survival time.At present,animal models of ovarian cancer are mainly based on Western medicine models,and research on animal models consistent with traditional Chinese medicine syndromes is rare.Therefore,the improvement direction of ovarian cancer animal models and the necessity of improving the evaluation system are proposed,so as to make the animal models of ovarian cancer more clinical,and provide a theoretical basis for the determination of the efficacy of traditional Chinese medicine and the discussion of pharmacological effects of ovarian cancer,and provide a theoretical basis for the subsequent research on the pathogenesis and treatment measures of ovarian cancer,in order to improve the model of combining ovarian cancer symptoms in line with the clinical characteristics of traditio

关 键 词：卵巢癌 动物模型 病证结合 中西医 

分 类 号：R711.750[医药卫生—妇产科学]