基于Th17/Treg平衡轴探讨中医药治疗慢性荨麻疹的作用及机制研究  

To Explore the Effect And Mechanism of Traditional Chinese Medicine on Chronic Urticaria Based on Th17/Treg Balance Axis

作　　者：张勇龙 逯子衡 林晓云 王艳君[1] Zhang Yonglong;Lu Ziheng;Lin Xiaoyun;Wang Yanjun(The First Affiliated Hospital of Hebei College of Traditional Chinese Medicine,Shijiazhuang 050011,China)

机构地区：[1]河北中医学院第一附属医院,石家庄050011

出　　处：《世界科学技术-中医药现代化》2023年第6期2159-2167,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家科学技术部国家重点研发计划“中医药现代化研究”重点专项(2017YFC1703605):针刺治疗慢性荨麻疹的注册登记研究,负责人:王艳君;河北省科技厅外专局河北省引进国外智力项目(冀科专函【2022】11号):针刺拔罐治疗慢性荨麻疹临床与作用机制研究,负责人:王艳君。

摘　　要：免疫失衡机制在慢性荨麻疹的发病机制中占据主导地位,既往认为Th1/Th2失衡是慢性荨麻疹发生的主要免疫机制。但近年来,研究发现Th17/Treg失衡亦是导致慢性荨麻疹发生的重要免疫机制。中医对慢性荨麻疹病因病机的认识比较全面,一般多认为其发病多为先天禀赋不足,卫表不固,复感六淫之邪;或饮食失节,积热生风;或久病虚弱,气血失养。故治疗上,实证宜疏风散邪,清利湿热;虚证宜补益气血,扶助正气;虚实夹杂则扶正与祛邪并重。有关中医药对慢性荨麻疹以及免疫性疾病中Th17/Treg平衡影响的研究情况来看,主要涉及的有中药复方、中药有效成分或单味中药。利用现代药理学研究来阐释中医药治疗慢性荨麻疹及各种免疫性疾病是现阶段的研究热点,不仅为中医药治疗慢性荨麻疹提供科学依据,也为更多免疫性疾病患者带来益处。故笔者通过阐释Th17、Treg细胞在慢性荨麻疹中的影响,对近年来中医药关于慢性荨麻疹以及其他免疫性疾病中Th17/Treg免疫失衡影响的研究进展作一综述。Immune imbalance is believed to play a dominant role in the pathogenesis of chronic urticaria.While Th1/Th2 imbalance used to be considered as the main contributing factor of the development of chronic urticaria.Recently,Th17/Treg imbalance is found to be an important immune mechanism leading to the development of chronic urticaria.To be more specific,according to traditional Chinese medicine(TCM)'s comprehensive understanding of the etiology of chronic urticaria.it is generally believed that the pathogenesis of chronic urticaria is due to a lack of innate endowment,a lack of solidity of the body surface,and repeated exposure to six pathogenic factors.Another possible reason lies with dietary disorders that generate heat and wind or chronic illness and weakness and loss of nourishment of qi and blood.Therefore,in terms of the treatment,from the perspective of sthenia syndrome,it is advisable to remove the wind and disperse the pathogenic factors and clear the dampness and heat.From the perspective of asthenia syndrome,it is advisable to nourish the qi and blood and support the righteousness.As for mixed excess and deficiency,both support the healthy atmosphere and dispel the pathogenic factors are important.Regarding the effects of TCM on the balance of Th17/Treg in chronic urticaria and immune diseases,it mainly involved herbal compounding,herbal active ingredients and single herbs.However,the research attention has been drawn to investigating the role of TCM in the treatment of chronic urticaria and various immune diseases based on the research outcomes in modern pharmacological research.This can not only provide scientific evidence for TCM treatment of chronic urticaria,but also bring benefits to more patients with immune diseases.Therefore,the author reviews the recent research progress of TCM on the effects of Th17/Treg immune imbalance in chronic urticaria and other immune diseases by explaining the effects of Th17 and Treg cells in chronic urticaria.

关 键 词：慢性荨麻疹 TH17细胞 TREG细胞 中医药 复方 单体 

分 类 号：R285[医药卫生—中药学]