黄花蒿的化学成分与药理作用研究进展及质量标志物的预测分析  

Advances in Chemical Constituents and Pharmacological Effects of Artemisia annua and Prediction of Quality Markers

作　　者：郭源辉 刘婕[1,2,3,4] 刘传鑫[1,2,3,4] 姜宏卫 Guo Yuanhui;Liu Jie;Liu Chuanxin;Jiang Hongwei(Clinical Medical College of Henan University of Science and Technology,Luoyang 471003,China;Endocrine Metabolism Center of the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China;Henan Provincial Key Laboratory of Genetic Rare Diseases,Luoyang 471003,China;National Metabolic Disease Clinical Medical Research Center Luoyang Branch,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院,洛阳471003 [2]河南科技大学第一附属医院内分泌代谢中心,洛阳471003 [3]河南省遗传罕见病医学重点实验室,洛阳471003 [4]国家代谢性疾病临床医学研究中心洛阳分中心,洛阳471003

出　　处：《世界科学技术-中医药现代化》2023年第4期1309-1332,共24页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200570):双氢青蒿素通过抑制TGF-β/Smads信号通路改善db/db小鼠糖尿病肾病纤维化,主持人:刘婕

摘　　要：黄花蒿为一味传统中药,历史悠久,始载于《五十二病方》。近年来备受国内外研究者关注,已成为热点研究中药之一。黄花蒿化学成分多样,药理活性广泛。本文以中药质量标志物理论体系为指导,结合现今研究成果,对黄花蒿质量标志物进行预测分析,为黄花蒿质量控制、药效评价与机制研究提供参考。Artemisia annua is a traditional Chinese medicine.It has a long history and is first recorded in the"Prescriptions for Fifty-two Diseases".In recent years,it has attracted the attention of domestic and foreign researchers,and has become one of the hot research Chinese medicine.Artemisia annua has diverse chemical constituents and extensive pharmacological activities.In this paper,guided by the theoretical system of quality markers of traditional Chinese medicine,combined with current research results,the quality markers of Artemisia annua were predicted and analyzed to provide reference for quality control,efficacy evaluation and mechanism research of Artemisia annua.

关 键 词：黄花蒿 质量标志物 倍半萜类 黄酮类 挥发油类 

分 类 号：R285[医药卫生—中药学]