肥胖中医证候动物模型研究进展  

Research Progress on Animal Models of TCM Syndromes of Obesity

作　　者：游翕 张林[2] 姚俊鹏 李瑛[3] You Xi;Zhang Lin;Yao Junpeng;Li Ying(College of Acupuncture and Massage,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;General Practice of West China Hospital of Sichuan University,Chengdu 610000,China;College of Postgraduate,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学针灸推拿学院,成都610075 [2]四川大学华西医院全科医学科,成都610000 [3]成都中医药大学研究生院,成都610075

出　　处：《世界科学技术-中医药现代化》2022年第9期3332-3338,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会面上项目(81673803):基于Tsc1-mTOR甲基化修饰介导自噬探讨电针减肥效应差异化机制研究,负责人:张林;成都中医药大学杏林学者项目(QNXZ2018033):电针通过下丘脑miR-103介导mTOR信号通路减重的机制研究,负责人:张林

摘　　要：肥胖是一种常见的慢性代谢性疾病,中医药治疗有一定优势,但其治疗机制至今尚未明确,限制了中医药在此领域的发展。因此,建立一套具有中医特色的肥胖动物模型评价体系对进一步深入研究具有重要意义。本文通过整理分析近年来肥胖中脾胃虚弱证、脾肾阳虚证、痰湿证、痰瘀互结证、肝胃郁热证、脾虚湿盛证和肝郁脾虚证的造模方法,发现存在肥胖模型评价标准不统一、证候造模方法和评价方法不严谨,“病”“证”结合不紧密、以方测证有缺点等问题。可见,肥胖的中医证候模型及其评价体系的建立还要立足在中医肥胖理论和临床的实践中,进行更深入的研究。Obesity is a common chronic metabolic disease.Traditional Chinese medicine for obesity has certain advantages,but its therapeutic mechanism is still unclear,which limits the development of traditional Chinese medicine in this field of obesity.Therefore,it is of great significance to establish a set of obesity animal model evaluation system with the characteristics of traditional Chinese medicine for further research.In this paper,we analyzed the modeling methods of obese animals in recent years,such as spleen-stomach weakness,spleen-kidney yang deficiency,phlegmdampness pattern,syndrome of intermingled phlegm and blood stasis,syndrome of heat stagnation in liver and stomach,spleen vacuity with damp encumbrance and liver depression and spleen deficiency.We found that there are some problems,such as the evaluation standard of obese model,the method of syndrome modeling and evaluation,the combination of disease and syndrome,and testing syndrome by formula.Therefore,in order to more in-depth research,the establishment of traditional Chinese medicine syndrome model and evaluation system of obesity should be based on traditional Chinese medicine obesity theory and clinical practice.

关 键 词：肥胖 中医证候 动物模型 综述 

分 类 号：R259[医药卫生—中西医结合] R-332[医药卫生—中医内科学]