线粒体自噬与神经退行性疾病的关系及针灸调控机制探讨  

The Relationship between Mitochondrial Autophagy and Neurodegenerative Diseases and the Discussion on the Regulatory Mechanism of Acupuncture

作　　者：张利 袁懿芸 吴长乐 王强 王渊 邢文文[2] 乔海法 杨晓航 刘奇 Zhang Li;Yuan Yiyun;Wu Changle;Wang Qiang;Wang Yuan;Xing Wenwen;Qiao Haifa;Yang Xiaohang;Liu Qi(School of Acupuncture,Moxibustion and Tuina,Shaanxi University of Chinese Medicine,Xi'an 712046,China;School of Basic Medicine,Shaanxi University of Chinese Medicine,Xi'an 712046,China)

机构地区：[1]陕西中医药大学针灸推拿学院,西安712046 [2]陕西中医药大学基础医学院,西安712046

出　　处：《世界科学技术-中医药现代化》2022年第8期3242-3248,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会面上项目(82074567):针刺调控SIRT3延续性研究——保护线粒体自噬-合成平衡促AD小鼠突触可塑性机制,负责人:刘奇;国家自然科学基金青年科学基金项目(81704186):针刺调控SIRT3介导线粒体保护作用改善AD小鼠学习记忆的机制研究,负责人:刘奇;陕西省自然科学基础研究计划(2017JQ8020):基于SIRT3介导线粒体代谢酶去乙酰化的针刺防治AD机制研究,负责人:刘奇

摘　　要：线粒体自噬在线粒体数量和质量控制以及线粒体正常功能的维持中具有重要作用,与阿尔兹海默病、帕金森氏病等神经退行性疾病的发生发展密切相关。线粒体自噬过度和自噬障碍以及自噬相关基因发生突变等均影响退行性疾病病理进程。本文就线粒体自噬途径、线粒体自噬与神经退行性疾病的关系等作一综述,并探讨针灸调控线粒体自噬防治神经退行性疾病的可能机制,以期进一步丰富针灸防治神经退行性疾病机制的内涵。Mitochondrial autophagy plays an important role in the control of mitochondrial quantity and quality and in the maintenance of normal mitochondrial function,and is closely associated with the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.Mitochondrial autophagy and autophagy disorders,as well as mutations in autophagy-related genes,are involved in the pathological process of degenerative diseases.In this paper,we review the Mitochondrial autophagy pathway,the relationship between mitochondrial autophagy and neurodegenerative diseases,and explore the possible mechanisms by which acupuncture regulates mitochondrial autophagy to prevent and treat neurodegenerative diseases,in order to further enrich the connotation of the prevention and treatment mechanism of acupuncture in neurodegenerative diseases.

关 键 词：线粒体自噬 针灸 神经退行性疾病 综述 

分 类 号：R245[医药卫生—针灸推拿学]