表观遗传学在中医药研究中应用的文献计量分析  

Bibliometric Analysis of Applying Epigenetics in TCM Research

作　　者：姜俊杰[1] 张华 刘玉庆[3] 申浩 于洋 谢雁鸣[1] Jiang Junjie;Zhang Hua;Liu Yuqing;Shen Hao;Yu Yang;Xie Yanming(Institute of Clinical Basic Medicine,Chinese Academy of Traditional Chinese Medicine,Beijing,100700,China;Administrative Matters Acceptance Service and Complaints Reporting Center of the State Drug Administration,Beijing,100053,China;Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing,100700,China;Xindian Community Health Service Center,Fengtai District,Beijing,100072,China;Changping District Integrated Traditional Chinese and Western Medicine Hospital,Beijing,100096,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]国家药品监督管理局行政事项受理服务和投诉举报中心,北京100053 [3]北京中医药大学东直门医院,北京100700 [4]丰台区长辛店社区卫生服务中心,北京100072 [5]昌平区中西医结合医院,北京100096

出　　处：《世界科学技术-中医药现代化》2020年第7期2217-2223,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金青年基金(81603517):基于ABCB1甲基化的肾阳虚与肝肾阴虚绝经后骨质疏松症患者骨碎补总黄酮代谢差异机制的研究;负责人:姜俊杰

摘　　要：目的为总结表观遗传学在中医药研究中的应用情况。方法以CNKI为检索数据库,检索时间是建库时间至2019年1月9日,检索式是SU=(’表观遗传’+’甲基化’+’组蛋白修饰’+’miRNA’)*(’中医’+’中药’+’针’+’灸’+’证’);采用Notexpress进行文献筛选;利用EXCEL2016进行文献计量分析,分析内容包括:各年份、各地区及各研究单位发表文献数量、文献类型、发表期刊、表观遗传机制内容。研究方向、所涉及疾病、研究方法。结果近3年,中医药表观遗传研究的发文量达到高峰;发文量较多的集中在北京、广东、上海等发达地区;北京中医药大学是发文量最多的单位;大部分以期刊论文或学位论文的形式发表;发文量最多的是杂志中华中医药杂志;研究内容以miRNA、DNA甲基化为主;研究方向主要是中药药效机制、证候本质研究;研究的热点疾病是肿瘤、冠心病;临床研究及基础研究均有涉及。结论表观遗传在中医药领域的应用尚属于探索阶段,无法达到精准的程度,建议加强机构间合作,使中医药表观遗传研究更加具体和深入。Objective:To understand the application of epigenetics in the study of traditional Chinese medicine.METHODS CNKI was used as the search database and the search time was from the establishment time of database to January 9,2019.The search formula was SU=(’epigenetic’+’methylation’+’histone modification’+’microRNA’)*(’traditional Chinese medicine’+’traditional Chinese medicine’+’needle’+’moxibustion’+’syndrome’);Notexpress was used for literature screening;EXCEL 2016 was used for bibliometric analysis,which included the number of literatures published in different years,regions and research units,quantity,literature type,Journal publication,epigenetic mechanism content,research direction,diseases involved and research methods.RESULTS In the past three years,the amount of publications on epigenetics of TCM reached its peak;the amount of publications was concentrated in developed areas such as Beijing,Guangdong and Shanghai;Beijing University of Traditional Chinese Medicine was the largest publishing institution;most of them were published in the form of papers or dissertations;the largest number of publications were Chinese Journal of TCM;the main research contents were microRNA and DNA methylation;The research direction is mainly on the mechanism of pharmacodynamics and the essence of syndromes of traditional Chinese medicine;the hot spots of research are cancer and coronary heart disease;clinical research and basic research are involved.CONCLUSION The application of epigenetics in the field of traditional Chinese medicine is still in the exploratory stage and can not reach the exact level.It is suggested that inter-agency cooperation should be strengthened to make the study of epigenetics of traditional Chinese medicine more specific and in-depth.

关 键 词：中医 表观遗传 文献计量 

分 类 号：R2-03[医药卫生—中医学] G353.1[文化科学—情报学]