基于关联规则和因子分析的国医大师班秀文治疗带下病用药规律分析  

Association Mining of Chinese Medicine Prescription of Leucorrhea Diseases by Ban Xiuwen Based on Apriori Algorithm Andfactor Analysis

作　　者：刘秋霞[1] 郑景辉[2] 戴铭[1] Liu Qiuxia;Zheng Jinghui;Dai Ming(Guangxi Key Laboratory of Basic Research of Traditional Chinese Medicine,Guangxi University of Chinese Medicine,Nanning 530200,China;Ruikang Hospital Affiliated Guangxi University of Chinese Medicine,Nanning,530200,China)

机构地区：[1]广西中医药大学广西中医基础研究重点实验室,南宁530200 [2]广西中医药大学附属瑞康医院,南宁530200

出　　处：《世界科学技术-中医药现代化》2020年第5期1601-1607,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家出版基金管理委员会“十二五”国家重点图书出版规划项目:班秀文医学著作集,负责人:戴铭;广西科学技术厅面上项目(2014GXNSFAA118230):国医大师班秀文防治月经病学术思想与证治规律研究,负责人:戴铭;广西壮族自治区卫生厅中医药科技专项(GZLC14-21):班氏养血通脉汤治疗原发性痛经的临床研究,负责人:刘秋霞

摘　　要：目的分析、挖掘国医大师班秀文教授治疗带下病的辨证思维和用药规律。方法收集班秀文教授治疗带下病的病案117例,运用IBM SPSS Modeler14.1、CytoScape3.6.1和SPSS Statistics21软件,对药物进行频次计算、关联分析和因子分析。结果117例患者共计289诊次,处方298首,使用药物188味。病例数量排名前3位的证型为脾虚证、湿热证和湿瘀证;药物使用频次前5位的依次是白芍(165)、甘草(148)、白术(138)、茯苓(117)、土茯苓(115);药类使用频次排前5位的依次为补气药(274)、补血药(201)、利水消肿药(189)、活血调经药(154)和清热解毒药(125)。支持度≥0.1,置信度≥0.8的常见药对有11对,药物3项关联有34项。药物共现关系分析图显示白术、甘草、白芍、党参、苍术、土茯苓、制附子的中介中心度较高。脾虚证、湿热证和湿瘀证分别提取出27个、30个和25个药物组合公因子。结论班秀文治疗带下病时注重健脾除湿、经带并治和从肾治带,久带则标本兼顾,补气养血益阴,其学术观点与临证经验值得进一步研究与推广。Objective To analyze Chinese medicine master Ban Xiuwen’s medication rule of Leucorrhea diseases using data mining technology.Method Prescriptions from 117 cases by Professor Ban in treating of Leucorrhea diseases were collected.The association rules and factor analysiswereanalyzed byIBM SPSS Modeler 14.1,CytoScape 3.6.1 and SPSS Statistics 21 software.Result Totally 298 prescriptions from 117 patients,contaied 188 herbs.The top 5 most common type of syndrome in Leucorrhea diseases we respleen-deficiency syndrome,damp-heat syndromeand blood silt-damp pathogen syndrome.The top 5 most commonly used herbs wereBaishao[RadixPaeoniaealbae,白芍](165),Gancao[RadixGlycyrrhizae,甘草](148),Baizhu[RhizomaAtractylodisMacrocephalae,白术](138),Fuling[Poriacocos,茯苓](117)andTufuling[Smilax glabra,土茯苓](115).The top 5 most classified herbs were Qi-tonifying drugs(274),bloodtonifying drugs(201),diuresis-inducing and edema-leviating drugs(189),blood-activating and menstruation-regulating drugs(154)and heat-clearing and detoxicating drugs(125).There were 11 pairs of common couplet medicines and 343-linked medication used with support de-gree)0.1 and confidence≥0.8.The drug relationship analysis chart showsBaizhu[RhizomaAtractylodisMacrocephalae,白术],Gancao[RadixGlycyrrhizae,甘草],Baishao[RadixPaeoniaealbae,白芍],Dangshen[Radix codonopsis,党参],Cangzhu[Atractylodes,苍术],Tufuling[Smilax glabra,土茯苓]and Zhifuzi[Radix aconite lateralispreparata,制附子]is higher in drug co-occurrence relation degree.Twenty-seven,30 and 25 common factors were extracted from spleen-deficiency syndrome,damp-heat syndrome and blood silt-damp pathogen syndrome.Conclusion Professor Banemphasize Invigorate the spleen to damp elimination in treating Leucorrhea diseases,in addition regulatingkidney,andbenefiting Qi,nourishing blood and Yinin patients with longer course.So the medication rule of professor Ban in treating Leucorrhea diseases deserves to be researched and promoted.

关 键 词：班秀文 带下病 关联规则 因子分析 用药规律 

分 类 号：R249[医药卫生—中医临床基础] R271.13[医药卫生—中医学]