“全国名中医”潘敏求治疗肝积的方剂用药规律分析  

Analyze Prescription Rules of Famouls Doctor of Traditional Chinese Medicine Pan Min-qiu Treatment for Liver Accumulation

作　　者：潘宇 龚辉 徐菲[5,6] 吴芳芳 蒋益兰 李顺祥 Pan Yu;Gong Hui;Xu Fei;Wu Fangfang;Jiang Yilan;Li Shunxiang(School of Integrated Chinese and Western Medicine,Hunan University of Chinese Medicine,Changsha 10208,China;Engineering Lab for Endangered Medicinal Resources of Southwest China,Nanning 530023,China;School of Tranditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;Department of Oncology,Affiliated Hospital of Hunan Institute of Traditional Chinese Medicine,Changsha 410006,China;School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410028,China;Hunan Engineering Research Center of Bioactive Substance Discovery of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学中西医结合学院,长沙410208 [2]西南濒危药用植物资源开发国家工程实验室,南宁530023 [3]湖南中医药大学中医学院,长沙410208 [4]湖南省中医药研究院附属医院肿瘤科,长沙410006 [5]湖南中医药大学药学院,长沙410208 [6]湖南省中药活性物质筛选工程技术研究中心,长沙410208

出　　处：《世界科学技术-中医药现代化》2020年第4期1108-1115,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然基金委员会地区科学基金项目(81960797):基于整合药理学和方证代谢组学对肝复乐抗非酒精性肝病的药效机制研究,负责人:潘宇;湖南省科技厅重点研发计划(2016SK2033):抗肝癌中药肝复乐的物质基础与产品二次升级研究,负责人:李顺祥;中国博士后科学基金面上项目(2017M622585):清肝降脂壮药复方抗非酒精性脂肪肝病的系统生物学研究,负责人:潘宇

摘　　要：为深入分析潘敏求治疗肝积的方剂用药特点,使用中医传承辅助平台系统构建151首潘敏求治疗肝积门诊的方剂数据库,依次分析肝积的流行病学分布特点、临床症状高频分布、证候分布、四气五味、归经分布、高频用药组合、组方规律、新方配伍组合,运用"频次分析"筛选46味高频单味药(频次≥15),利用"关联规则"筛选15味高频中药配伍组合,43组核心药物组合(支持度≥30%,置信度≥90%),进而通过"无监督的熵层次聚类"(相关度=8,惩罚度=2)提取了7组新方组合。潘敏求用药以"健脾理气、化瘀软坚、清热解毒"为主,强调中医辨证论治,体现调理脏腑、补益气血、攻补兼施、病证结合的治则治法。To deeply investigate the 151 herbal prescriptions of Pan Min-qiu in treatment of liver accumulation based onthe traditional Chinese medicine inheritance support system software(TCMISS)that collecting and establishing a typicaldatabase.Four properties,five tastes,channel tropism,frequency count,Chinese herbal prescriptions rules and the newprescriptions were analyzed so as to dig out the prescription rules.There were 46 high frequency single herbs were sceened byfrequency analysis with a frequency more than 15.Then 15 high high frequency herbal combinations and 43 core drugcombinations with a support more than 30%and confidence more than 90%,which were sceened by association rules.Furthermore 7 new prescriptions with a relevancy equal to 8 and punishment equal to 2 that used by unsupervisedhierarchical entropy clustering.It was found out that these drugs mainly had the effects of liver nourishing and soothing,soft-moist and dredging-tonifying,supporting right and dispeling evil,cooperating with the method of calming the liver andresolving hard lump according to the actual situation.It reflected the thought of treatment based on syndrome differentiationin Traditional Chinese Medicine,and embodied the treatment principles and methods of regulating viscera,tonifying qi andblood,attacking and tonifying simultaneously,and combining disease and syndrome.

关 键 词：潘敏求 肝积 清热解毒 化瘀软坚 健脾理气 用药规律 

分 类 号：R256.4[医药卫生—中医内科学]