大鼠新生期皮下注射谷氨酸单钠对成年后下丘脑ACTH神经元和正中隆起CRF神经纤维免疫反应性的影响  

EFFECT OF NEONATALLY ADMINISTERED MONOSODIUM GLUTAMATE ON THE IMMUNOREACTIVITY OF ACTH AND CRF NEURONES OF HYPOTHALAMUS IN THE RAT

作　　者：张景行[1] Valatx J.L Luciene L. Jouvet M. Zhang Jingxing;Valatx J.L.(Department of Physiology,Anhui Medical University;Laboratory of Experimental Medicine,University of ClaudeBernard,France)

机构地区：[1]安徽医科大学生理学教研室 [2]法国克劳·伯尔纳大学实验医学研究所

出　　处：《神经解剖学杂志》1988年第1期61-64,129,共5页Chinese Journal of Neuroanatomy

摘　　要：本文采用过氧化酶—抗过氧化酶(PAP)的免疫组织化学和荧光免疫组织化学的方法,研究了新生期大鼠皮下注射谷氨酸单纳(MSG)对成年后下丘脑弓状核促肾上腺皮质激素(ACTH)神经元和正中隆起内促肾上腺皮质激素释放因子(CRF)神经纤维免疫反应的影响。新生期MSG处理后,弓状核中ACTH神经元的数目明显减少,正中隆起CRF样免疫反应末稍也大大减少,减少程度随MSG剂量增大而增加。提示MSG通过损伤前阿黑皮素(POMC)衍生的神经多肽,从而影响下丘脑—垂体—肾上腺皮质轴的功能。Effect of neonatal administration of monosodium glutamate on the immunoreactivity of adrenocorticotrepic hormone(ACTH)and corticotropin-releasing factor(CRF)neurones in the mature rat hypothalamus have been studied by the PAP and the immuno-fluoreseent methods,the result showed that MSG selectively damaged ACTH neurons in the hypothalamic arcuate nucleus and CRF immunoreactive terminals in the median eminence.And the degree of damage increased with the enlargement of the dosage of MSG.It is suggested that MSG could influence the function of the hypothalamic-pituitary-adrenal cortex axis by destruction some neuropeptides derived from pro-opio-melanocortin(POMC).

关 键 词：谷氨酸单纳(MSG) 免疫组化 弓状核 正中隆起 

分 类 号：R28[医药卫生—中药学]