穹窿下器官在大鼠交替性饮水行为中的神经内分泌作用  

THE EFFECT OF SUBFORNICAL ORGAN LESIONS ON ALTERNATION BEHAVIOR IN RATS

作　　者：杨振芳[1] 张殿明[1] 田德润[1] 唐五凤 吴樾 Yang Zhenfang;Zhang Dianming;Tian Derun;Tang Wufeng;Wu Yue(Tianjin Medical College)

机构地区：[1]天津医学院解剖学教研室、天津市内分泌研究所神经内分泌组

出　　处：《神经解剖学杂志》1987年第1期89-92,共4页Chinese Journal of Neuroanatomy

基　　金：中国科学院科学基金资助的课题

摘　　要：电坏坏Sprague-Dawley大鼠的穹窿下器官(SFO)后,脑室内注入血管紧张素Ⅱ100ng,大鼠在T迷宫内左右交替性饮水行为受到明显的抑制,交替性方向正确率明显降低,跑速亦显著减慢,提示SFO在血管紧张素Ⅱ引起的交替性饮水行为中起重要作用。在破坏了SFO同时又破坏了视前正中核的动物,虽然SFO破坏较小,也能阻断动物的左右交替性饮水行为。本文的实验还提示了血管紧张素Ⅱ可作用于SFO和AV3V(第三脑室前腹部)两者。In previous studies we and other workers have demonstrated that the subfornical organ(SFO)is the important receptor site for the drinking behavior induced by the intracranial injection of angiotensin Ⅱ.In order to further investigate the alternation behavior in a T-maze,effects of intracranial angiotensin injections were compared in the rat before and after electrolytic lesions of SFO.Lesions of SFO eliminated the alternation behavior in rats in the T-maze after physiologically meaningful doses of angiotensin Ⅱ given intracerebroventricularly.The results indicated that the SFO plays an important role in the alternation behavior stimulated by the injection of angiotensin Ⅱ into the ventricle.

关 键 词：穹窿下器官 血管紧张素 视前正中核 

分 类 号：S85[农业科学—兽医学]