中医药对慢性乙型肝炎免疫调节作用概述  

Immunomodulatory effects of traditional Chinese medicine on chronic hepatitis B

作　　者：刘影 徐汉辰[2] 王磊[1] LIU Ying;XU Hanchen;WANG Lei(Department of Hepatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Institute of Spleen and Stomach Diseases,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院肝病科,上海200032 [2]上海中医药大学附属龙华医院,上海中医药大学脾胃病研究所,上海200032

出　　处：《上海中医药杂志》2022年第5期93-97,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81973725)

摘　　要：慢性乙型肝炎(CHB)是威胁人类健康的重大公共卫生问题,机体免疫应答不足是造成乙型肝炎病毒(HBV)持续感染、肝脏损伤加重及疾病迁延不愈的重要原因。从固有免疫、适应性免疫角度,综述中医药对CHB的免疫调节作用。中医药可以通过调节巨噬细胞吞噬功能、调节树突状细胞(DC)功能、提高自然杀伤细胞(NK)杀伤活性、改善辅助性T细胞失衡状态、增强T细胞亚群的免疫应答能力等途径调节CHB患者的免疫状态。Chronic hepatitis B(CHB)is a major public health problem that threatens human health.Inadequate immune response is an important cause of persistent hepatitis B virus(HBV)infection,aggravated liver damage and prolonged course of disease.The immunomodulatory effects of traditional Chinese medicine(TCM)on CHB were reviewed from the perspectives of innate immunity and adaptive immunity.TCM can regulate the immune status of CHB patients by regulating macrophage phagocytosis and dendritic cell(DC)immune function,increasing natural killer cell(NK)activity,improving the imbalance of helper T subsets and enhancing the immune response capacity of T cell subsets.

关 键 词：慢性乙型肝炎 中药 免疫调节 固有免疫 适应性免疫 综述 

分 类 号：R259[医药卫生—中西医结合]