参葛方配合生活饮食干预治疗非酒精性脂肪性肝病的临床研究  

Clinical study of Shenge Formula combined with diet intervention in the treatment of non-alcoholic fatty liver disease

作　　者：吕佳[1] 高月求[1] 方淼 张鑫[1] 高亚婷[1] LYU Jia;GAO Yueqiu;FANG Miao;ZHANG Xin;GAO Yating(Department of Hepatology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院肝病科,上海201203

出　　处：《上海中医药杂志》2020年第S01期38-40,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81874436,81774256);国家科技重大专项(2018ZX10725504);上海申康市级医院新兴前沿技术联合攻关项目(SHDC12016121);上海中医药大学附属曙光医院四明基金项目(SGKJ-201705).

摘　　要：目的观察参葛方配合生活饮食干预对非酒精性脂肪性肝病患者的临床疗效。方法将73例非酒精性脂肪肝患者按照随机数字的方法分为治疗组(n=38)和对照组(n=35),随访24周,脱落8例(治疗组和对照组各4例)。所有患者均给予基础治疗(中等量有氧运动每周4次、地中海饮食),治疗组在基础治疗上加用参葛方,对照组在基础治疗上加用安慰剂。两组疗程均为24周,观察两组患者的中医症状积分、肝功能(ALT、AST)、血脂(TC、TG)。结果治疗后,治疗组和对照组的总有效率分别为100%(34例/34例)和48.39%(15例/31例),组间临床疗效差异具有统计学意义(P<0.05)。治疗后,治疗组TG、TC、AST指标较治疗前有改善,差异有统计学意义(P<0.05);两组患者TG、TC指标均有所改善,且治疗组改善程度优于对照组,差异有统计学意义(P<0.05)。结论使用参葛方配合生活饮食治疗非酒精性脂肪性肝病,可以显著缓解患者症状,改善血脂指标,提高治疗效果。Objective To observe the clinical efficacy of Shenge Formula combined with diet intervention on patients with non-alcoholic fatty liver disease.Methods Seventy-three patients with non-alcoholic fatty liver disease were randomly divided into the treatment group(n=38)and control group(n=35)according to random number table.All patients were followed-up for 24 weeks,and 8 cases dropped out(4 cases in the treatment group and 4 cases in the control group).All patients were treated with basic treatment(moderate aerobic exercise 4 times a week and Mediterranean diet).Based on the basic treatment,the treatment group was treated with the Shenge Formula,and the control group was treated with the placebo,with a course of 24 weeks.The Chinese medical symptom score,liver function indexes(ALT and AST)and blood lipid levels(TC and TG)were observed in the two groups.Results After treatment,the total effective rates were 100%(34 cases/34 cases)in the treatment group and 48.39%(15 cases/31 cases)in the control group,respectively.There was statistically significant difference in clinical efficacy between the two groups(P<0.05).After treatment,the levels of TG,TC and AST in the treatment group were improved compared with those before treatment,with statistically significant differences(P<0.05).The levels of TG and TC were improved in the two groups,and the improvement in the treatment group was better than that in the control group,with statistically significant differences(P<0.05).Conclusion Shenge Formula combined with diet intervention can significantly alleviate the symptoms of patients with non-alcoholic fatty liver disease,improve the blood lipid indexes and enhance the therapeutic effects.

关 键 词：非酒精性脂肪性肝病 参葛方 临床研究 

分 类 号：R259[医药卫生—中西医结合]