基于双盲随机对照实验和重复测量设计评价中西医结合治疗慢性阻塞性肺疾病稳定期患者的临床疗效  

Evaluation of clinical efficacy of integrated traditional Chinese and western medicine in chronic obstructive pulmonary disease patients at stable stage based on randomized controlled trial and repeated measurement design

作　　者：张秀莲 黄品贤[2] 钱叶长 危蕾 刘芳英 王众福 黄国毅[1] ZHANG Xiulian;HUANG Pinxian;QIAN Yechang;WEI Lei;LIU Fangying;WANG Zhongfu;HUANG Guoyi(Baoshan Branch,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Information Science and Technology Research Center,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院宝山分院,上海200437 [2]上海中医药大学中医信息科学与技术研究中心,上海201203

出　　处：《上海中医药大学学报》2022年第S01期4-11,共8页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市卫计委中医药科研项目(2018LQ001);上海中医药大学后备卓越中医人才项目

摘　　要：目的:评价黄芪注射液穴位注射联合舒利迭治疗慢性阻塞性肺疾病(COPD)稳定期患者的临床疗效。方法:纳入95例COPD稳定期患者,采用随机双盲对照研究,将患者随机分为治疗组48例和对照组47例。治疗组患者给予黄芪注射液穴位注射联合舒利迭治疗,对照组患者给予生理盐水穴位注射联合舒利迭治疗,疗程均为3个月。每周应用COPD临床症状分级量化表记录患者的临床症状及治疗期间的不良反应发生情况。采用EpiData 3.0软件进行数据管理,SPSS 26.0统计软件进行数据分析。结果:两组COPD稳定期患者的临床疗效比较,差异有统计学意义(P<0.05),且临床疗效与治疗时间呈线性相关关系(P<0.05),组别是影响两组患者临床疗效评价的主要因素,治疗组的临床疗效优于对照组。结论:黄芪注射液穴位注射联合舒利迭治疗COPD稳定期患者的临床疗效优于舒利迭单药治疗,且临床疗效随治疗时间的延长而提高,该治疗方案安全有效,临床中适当延长治疗疗程能使患者受益更多。Objective:To evaluate the clinical efficacy of acupoint injection of astragalus injection combined with seretide on chronic obstructive pulmonary disease(COPD)at stable stage.Methods:Ninety-five patients with stable COPD were enrolled in a randomized double-blind controlled study,and randomly divided into the treatment group(n=48)and the control group(n=47).The patients in the treatment group were given acupoint injection of astragalus injection combined with seretide,and the patients in the control group were given normal saline injection combined with seretide for 3 months.The clinical symptoms and the occurrence of adverse reactions during treatment were recorded weekly with COPD clinical symptom grading quantification table.EpiData3.0 software was used for data management,and SPSS 26.0 statistical software was used for data analysis.Results:There was statistically significant difference between the two groups in the clinical efficacy of patients with stable COPD(P<0.05).And there was a linear correlation between the clinical efficacy and treatment time(P<0.05).Group was the main factor affecting the clinical efficacy evaluation of the two groups,and the clinical efficacy of the treatment group was better than that of the control group.Conclusion:The clinical efficacy of astragalus injection combined with seretide in the treatment of stable COPD is better than that of seretide group,and the clinical efficacy increases with the extension of treatment time.This treatment method is safe and effective.In clinic,patients can benefit more by appropriately prolonging the treatment course.

关 键 词：慢性阻塞性肺疾病 稳定期 疗程 重复测量设计 疗效评价 

分 类 号：R563.9[医药卫生—呼吸系统]