吲达帕胺抗高血压及其对血细胞内外钙的影响  

ANTIHYPERTENSIVE EFFICIENCY OF INDAPAMIDE AND ITS EFFECT ON INNER AND OUTER GALCIUM OF BLOOD GELL

作　　者：赵光胜[1] 何正泽 陈实[1] 袁晓源[1] 庞庆祥[1] 翁俊 李俊卿 王佳懿 韩默先 俞明 毛秀珍 

机构地区：[1]上海市高血压研究所 [2]上海市日晖医院 [3]上海市长航医院

出　　处：《上海医学》1988年第12期709-712,共4页Shanghai Medical Journal

摘　　要：在50例原发性高血压患者经用吲达帕胺(Indapamide)治疗后,对影响血细胞内外钙代谢作了观察。发现患者在降压同时,血小板胞浆游离钙平行下降,全血游离钙上升。吲达帕胺有一定降压疗效,副反应小,作用时间长,剂量——效应范围窄,特别适用于在群体防治高血压的钙拮抗剂类抗高血压药。同时血清氯降低,血清磷升高,血浆肾素活性升高,血清总钙不变。未证实血游离钙或肾素活性和降压幅度之间存在联系。The effect of indapamide on inner and outer calcium of blood cell was studied in 50 cases with essential hypertension.The results showed that the concentration of platelet cytoplasmic free calcium was decreased,being parallel to the fall of blood pressure,while free calcium in blood,an outer calcium of blood cell,was increased.This denotes that indapamide is an antihypertensive drug with definite efficiency,less adverse effect,long action,and narrow dosage-effect range,being especially valuable for the community control of hy=pertension.Serum chloride was decreased and serum phosphate as well as plasma renin activty(PRA)was increased during treatment.However,total serum calcium was not changed.The link between blood free calcium or PRA and the depressive effect of indapamide was not ascertained.

关 键 词：吲达帕胺 血小板 抗高血压 胞浆游离钙 达帕 降压效应 原发性高血压患者 游离钙浓度 血细胞 

分 类 号：R54[医药卫生—心血管疾病]