乙型肝炎免疫球蛋白预防母婴传播乙型肝炎病毒效果的初步观察  

A PRELIMINARY REPORT ON PREVENTION OF MOTHER-INFANT TRANSMISSION OF HEPATITIS B WITH HEPATITIS B IMMUNOGLOBULIN

作　　者：吴长龙[1] 张天仁[1] 柴安卿 王德升[1] 贾荣章 汪健翔 胡善联 徐志一 金之菊 李翀 王素娟 胡时豪 华荣秋 桂凤莲 

机构地区：[1]卫生部上海生物制品研究所上海第一医学院流行病教研组 [2]上海市杨浦区卫生防疫站 [3]上海市徐汇区卫生防疫站

出　　处：《上海医学》1983年第3期145-148,共4页Shanghai Medical Journal

摘　　要：本文报道用乙型肝炎免疫球蛋白(HBIG)预防母婴传播乙型肝炎病毒的初步效果。对129例HBsAg阳性携带母亲的婴儿进行对照研究,在64例试验组内用HBIG多次被动免疫新生儿,用酶标检测技术;观察半年,只有12例为HBsAg阳性(18.75%)。而在65例对照组内,婴儿HBsAg阳性数为32例(49.23%),两组婴儿HBsAg阳性率差别有极显著意义(P<0.001)。另外在试验组中有20例母亲为HBeAg阳性,6个月内只有7例婴儿为HBsAg阳性(35%),而对照组有21例母亲为HBeAg阳性,其婴儿有19例是HBsAg阳性(90.48%)。两组婴儿HBsAg阳性率差别也有极显著意义(P<0.001)。本结果初步表明:用1∶2048(PHA)的国产HBIG预防母婴乙型肝炎病毒(HBV)传播具有良好的近期效果。Hepatitis B immunoglobulin(HBIG)was given as soon as possible after birth and then one dose every mo for 6 mo to 64 infants whose mothers were HBsAg positive.Al1 infants were followed up for 6 mo,only 12 infants(18.75%)became antigenemic(ELISA).while in 65 infants of HBsAg carrier mothers treated with normal immunoglobulin(placental)as control,32 infants became antigenemic(49.23%)(P<0.001).In addition,HBIG was administered after birth to 20 infants of HBsAg carrier mothers with positive antigen,only 7 infants became HBsAg positive(35%)within 6 too;whereas 19 infants became antigenemic(90.48%)out of 21 infants with HBeAg positive mothers(P<0.001).This preliminary results show that our specific immunoglobulin to HBsAg(PHA1:2,048)is effective in preventing of mother-infant transmission of HBV,if multiple doses are administered.

关 键 词：母婴传播 阳性率 垂直传播 乙型肝炎病毒 戴恩颗粒 HBSAG HBIG 乙型肝炎免疫球蛋白 

分 类 号：R51[医药卫生—内科学]