LncRNA与肝脏糖脂代谢的研究进展  

lncRNA in hepatic glucose and lipid metabolism: a review

作　　者：陈晓晓 孙琛 刘畅[1] 吴洁[1] Xiaoxiao Chen;Chen Sun;Chang Liu;Jie Wu(School of Life Science&Technology,China Pharmaceutical University,Nanjing 210000,Jiangsu,China)

机构地区：[1]中国药科大学,生命科学与技术学院,江苏南京210000

出　　处：《生物工程学报》2021年第1期40-52,共13页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(No.81800512);江苏省自然科学基金(No.BK20180554)资助

摘　　要：长链非编码RNA(Long non-coding RNA,lncRNA)因参与多个层级上的生物进程而成为当下生命科学领域的研究热点。LncRNA可以与DNA、RNA和蛋白质等生物分子结合,并进一步影响靶基因的转录、翻译以及翻译后修饰等过程,从而发挥在细胞生理代谢过程中的调控作用。目前研究显示,lncRNA通过多种途径在肝脏代谢中发挥重要作用。文中以lncRNA的功能及其与肝脏能量代谢和相关疾病的关系为着眼点,阐述了lncRNA发挥作用的机制以及未来的研究前景。In recent years,long non-coding RNA(lncRNA)has been proved to be involved in the regulation of biological processes at various levels,attracting research interests in life science.LncRNA possesses the unique capability and exert discrete effects on transcription,translation and post-translational modification of the target genes through interacting with DNA,RNA and protein.Current studies have revealed that lncRNA plays an important role in hepatic metabolism via diverse pathways.This review focuses on the function of lncRNA and its relationship with hepatic energy metabolism and the correlated diseases,to elucidate the underlying mechanisms and prospects of lncRNA researches.

关 键 词：长链非编码RNA 肝脏 糖代谢 脂代谢 

分 类 号：Q756[生物学—分子生物学]