肾淀粉样变性病的病理诊断与分型、分级的研究进展  

Research progress in pathological diagnosis,typing and grading of renal amyloidosis

作　　者：陈思羽 韩伟霞[1] 王晨[1] Chen Siyu;Han Weixia;Wang Chen(Department of Pathology,Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China)

机构地区：[1]山西医科大学第二医院病理科,山西太原030001

出　　处：《中华肾病研究电子杂志》2020年第2期86-89,共4页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

摘　　要：淀粉样变性病是由蛋白异常折叠后形成不溶性β-片层构型的淀粉样物发生异常沉积的一类代谢病,肾脏是最常受累的器官之一,诊断主要依赖肾穿刺病理活检。肾淀粉样变性病的临床及病理表现多样,病因学诊断及分型困难,无统一的病理学分级系统,临床缺乏有效的干预治疗。本文将对肾淀粉样变性病的病理表现、诊断及分型分级予以综述,以期为该疾病的诊断、治疗及预后评估提供依据。Amyloidosis is a disorder caused by extracellular deposition of misfolded proteins in an insoluble beta-pleated physical format.The kidney is a frequent site of amyloid deposition.Diagnosis of renal amyloidosis is based on the renal pathology biopsy.As the clinical features and pathological manifestations of renal amyloidosis are diverse,the diagnosis and typing of renal amyloidosis can sometimes be problematic.There is not a unified pathological grading system and lacks effective clinical interventions for renal amyloidosis.In this manuscript,we described the pathological manifestations,diagnosis,typing,and grading of renal amyloidosis,so as to provide a basis for the diagnosis,treatment,and prognosis evaluation of the disease.

关 键 词：肾淀粉样变性病 病理诊断 分型 病理分级 

分 类 号：R692[医药卫生—泌尿科学]