血清蛋白质β-折叠水平与冠心病的相关性  

Association between serum β-sheet level and coronary heart disease

作　　者：谢佳莹 祁佳[1,2] 宋铭 李育林 王迪 贾旭 张薇 钟明[1] 尚嫄嫄[1] XIE Jiaying;QI Jia;SONG Ming;LI Yulin;WANG Di;JIA Xu;ZHANG Wei;ZHONG Ming;SHANG Yuanyuan(The Key Laboratory of Cardiovascular Remodeling and Function Research,Chinese Ministry of Education,Chinese National Health Commission and Chinese Academy of Medical Sciences,The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine,Department of Cardiology,Qilu Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250012,Shandong,China;Department of Cardiology,Zibo Central Hospital,Zibo 255000,Shandong,China)

机构地区：[1]山东大学齐鲁医院心内科,山东大学教育部与国家卫健委心血管重构与功能研究重点实验室,山东济南250012 [2]淄博市中心医院心内科,山东淄博255000

出　　处：《山东大学学报（医学版）》2022年第1期21-26,共6页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金(81470560);山东省重点研发计划(2018GSF118002)

摘　　要：目的探讨血清β-折叠水平与冠心病的相关性,分析影响β-折叠水平的各种危险因素。方法选取223例冠心病患者(冠心病组)和56例健康查体人群(正常对照组)为研究对象,记录各组临床基本资料,留取外周血标本,采用硫磺素T染色法检测血清β-折叠水平。比较两组基本资料、血清β-折叠水平,多因素Logistic回归分析β-折叠水平与冠心病的相关性。结果冠心病组血清ThT荧光强度明显增加(P<0.05或P<0.01);冠心病组血清β-折叠的水平与腰臀比、年龄、心率、舒张压、糖化血红白蛋白(HbA1c)、低密度脂蛋白胆固醇(LDL-C)、血钠(Na)、白细胞计数和乳酸脱氢酶(LDH)水平呈正相关(P<0.05或P<0.01),也与高血压病史、吸烟史、糖尿病病史、高血脂病史及冠心病家族史呈正相关(P<0.05或P<0.01);血清β-折叠水平、性别、收缩压、甘油三酯(TG)、血糖(Glu)、同型半胱氨酸(Hcy)是冠心病的独立危险因素(P<0.05或P<0.01)。结论冠心病患者中血清β-折叠水平明显升高,是冠心病的独立危险因素,并且血清β-折叠的作用独立于LDL-C。Objective To investigate the relationship between serum β-sheet level and coronary heart disease(CHD).Methods A total of 223 CHD patients and 56 healthy controls were recruited.Baseline information,coronary lesion-related indicators and peripheral blood samples were collected.Serum protein β-sheet level was determined with thioflavin T fluorescence.The relationship between β-sheet level and CHD was analyzed with multivariate Logistic regression.Results Serum ThT fluorescence intensity increased significantly in CHD group(P<0.05 or P<0.01).The β-sheet level was positively correlated with waist-hip ratio,age,heart rate,diastolic blood pressure,glycosylated hemoglobin(HbA1 C),low density lipoprotein cholesterol(LDL-C),sodium(Na),white blood cell(WBC)and lactic dehydrogenase(LDH),as well as with the history of hypertension,smoking,diabetes,hyperlipidemia and family history of CHD(P<0.05 or P<0.01).Serum β-sheet level,sex,systolic blood pressure,triglyceride(TG),glucose(Glu)and homocysteine(Hcy)were independent risk factors for CHD(P<0.05 or P<0.01).Conclusion The serumβ-sheet level increases in CHD patients,which is an independent risk factor for CHD,and independent of known risk factors such as LDL-C.

关 键 词：Β-折叠 冠心病 低密度脂蛋白胆固醇 动脉粥样硬化 心血管残余风险 

分 类 号：R541.4[医药卫生—心血管疾病]